Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 2/20 | 0.37 |
| ▸ | TYRO3 | Q06418 | 2/20 | 0.37 |
| ▸ | MERTK | Q12866 | 2/20 | 0.37 |
| ▸ | GPBAR1 | Q8TDU6 | 2/20 | 0.36 |
| ▸ | GALR3 | O60755 | 1/20 | 0.36 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.34 |
| ▸ | TRPV4 | Q9HBA0 | 2/20 | 0.34 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.34 |
| ▸ | NAMPT | P43490 | 1/20 | 0.34 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.33 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | ELANE | P08246 | 1/20 | 0.32 |
| ▸ | SLC8A1 | P32418 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16229800 | 0.93 | SLC6A9 (0.36) | AXLTYRO3MERTKGALR3TRPV4 | |
| SCHEMBL16229792 | 0.91 | POLB (0.35) | SLC6A9NAMPTALKCYP19A1ALDH1A1 | |
| SCHEMBL16784652 | 0.90 | SLC8A1 (0.37) | SLC6A9SMN1; SMN2LMNASLC8A1 | |
| SCHEMBL16229766 | 0.90 | TP53 (0.35) | SLC6A9NAMPTALKSMN1; SMN2HSD11B1 | |
| SCHEMBL16784636 | 0.89 | GALR3 (0.41) | AXLTYRO3MERTKGALR3TRPV1 | |
| SCHEMBL16784648 | 0.87 | SLC6A9 (0.42) | AXLTYRO3MERTKGALR3SLC6A9 | |
| SCHEMBL16229803 | 0.86 | SLC6A9 (0.48) | GALR3SLC6A9ALDH1A1LMNA | |
| SCHEMBL16229810 | 0.84 | SLC6A9 (0.38) | AXLTYRO3MERTKGALR3SLC6A9 | |
| SCHEMBL16229806 | 0.84 | DGAT1 (0.35) | SLC6A9ALKALDH1A1LMNA | |
| SCHEMBL16784643 | 0.83 | GALR3 (0.43) | GALR3TRPV1TRPV4SLC6A9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9051280-B2 | Tetraline and indane derivatives, pharmaceutical compositions containing them, and their use in therapy | AbbVie Deutschland GmbH & Co. KG (DE) | 2015-06-09 | — | — | US | disclosed |
| US-8883839-B2 | Tetraline and indane derivatives, pharmaceutical compositions containing them, and their use in therapy | ABBOTT LABORATORIES (US) | 2014-11-11 | — | — | US | disclosed |