Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | SLC6A9 | P48067 | 2/20 | 0.36 |
| ▸ | NAMPT | P43490 | 2/20 | 0.36 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.36 |
| ▸ | SLC8A1 | P32418 | 1/20 | 0.34 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.33 |
| ▸ | GUSB | P08236 | 1/20 | 0.33 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.33 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.33 |
| ▸ | AURKA | O14965 | 1/20 | 0.33 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.33 |
| ▸ | MET | P08581 | 1/20 | 0.33 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.33 |
| ▸ | GNRHR | P30968 | 1/20 | 0.33 |
| ▸ | HTR1A | P08908 | 1/20 | 0.32 |
| ▸ | HTR7 | P34969 | 1/20 | 0.32 |
| ▸ | PLK1 | P53350 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16229789 | 0.92 | DGAT1 (0.40) | POLBKMT2ASLC6A9 | |
| SCHEMBL16784645 | 0.91 | SLC6A9 (0.41) | KMT2ASLC6A9SLC8A1METHTR1A | |
| SCHEMBL16784627 | 0.90 | TP53 (0.41) | KMT2ASLC6A9NAMPTCYP19A1SLC8A1 | |
| SCHEMBL16784636 | 0.90 | GALR3 (0.41) | SLC6A9NAMPTCYP19A1GUSBALK | |
| SCHEMBL16229792 | 0.89 | POLB (0.35) | POLBKMT2ASLC6A9NAMPTCYP19A1 | |
| SCHEMBL16784653 | 0.86 | SLC6A9 (0.51) | SLC6A9SLC8A1ALKHTR1AHTR7 | |
| SCHEMBL16229801 | 0.85 | SLC6A9 (0.51) | POLBKMT2ASLC6A9 | |
| SCHEMBL16229806 | 0.84 | DGAT1 (0.35) | POLBKMT2ASLC6A9METALK | |
| SCHEMBL16229753 | 0.83 | SLC6A9 (0.41) | POLBSLC6A9SLC8A1METALK | |
| SCHEMBL16229746 | 0.83 | HTT (0.40) | POLBSLC6A9CYP19A1SLC8A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9051280-B2 | Tetraline and indane derivatives, pharmaceutical compositions containing them, and their use in therapy | AbbVie Deutschland GmbH & Co. KG (DE) | 2015-06-09 | — | — | US | disclosed |