Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | MET | P08581 | 2/20 | 0.34 |
| ▸ | SLC8A1 | P32418 | 1/20 | 0.33 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.33 |
| ▸ | NAMPT | P43490 | 2/20 | 0.32 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.31 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.31 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.31 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.31 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | HTR1A | P08908 | 1/20 | 0.30 |
| ▸ | HTR7 | P34969 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | FSCN1 | Q16658 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16784652 | 0.93 | SLC8A1 (0.37) | POLBKMT2AMETSLC8A1SLC6A9 | |
| SCHEMBL16229806 | 0.92 | DGAT1 (0.35) | POLBKMT2AMETSLC6A9ALK | |
| SCHEMBL16229766 | 0.92 | TP53 (0.35) | METSLC8A1SLC6A9NAMPTALK | |
| SCHEMBL16229772 | 0.91 | AXL (0.37) | SLC8A1SLC6A9NAMPTALKSMN1; SMN2 | |
| SCHEMBL16784654 | 0.89 | POLB (0.40) | POLBKMT2AMETSLC8A1SLC6A9 | |
| SCHEMBL16229753 | 0.86 | SLC6A9 (0.41) | POLBMETSLC8A1SLC6A9ALK | |
| SCHEMBL16229760 | 0.85 | KMT2A (0.45) | KMT2ASLC8A1SLC6A9ALDH1A1 | |
| SCHEMBL16229798 | 0.85 | HTR6 (0.36) | SLC8A1SLC6A9PKMKDM4EHTR1A | |
| SCHEMBL16229761 | 0.85 | SLC6A9 (0.37) | KMT2ASLC6A9CHRM1ALDH1A1 | |
| SCHEMBL16229789 | 0.84 | DGAT1 (0.40) | POLBKMT2ASLC6A9ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9051280-B2 | Tetraline and indane derivatives, pharmaceutical compositions containing them, and their use in therapy | AbbVie Deutschland GmbH & Co. KG (DE) | 2015-06-09 | — | — | US | disclosed |
| US-8883839-B2 | Tetraline and indane derivatives, pharmaceutical compositions containing them, and their use in therapy | ABBOTT LABORATORIES (US) | 2014-11-11 | — | — | US | disclosed |