Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17928403 | 0.84 | ALDH1A1 (0.37) | NPC1ALDH1A1EPHX2MEN1KMT2A | |
| SCHEMBL11294325 | 0.68 | TSHR (0.49) | ALDH1A1 | |
| SCHEMBL21401948 | 0.68 | SLC22A2 (0.36) | NPC1ALDH1A1 | |
| SCHEMBL20002011 | 0.68 | SLC22A2 (0.36) | NPC1ALDH1A1 | |
| SCHEMBL2239665 | 0.68 | SLC22A2 (0.36) | NPC1ALDH1A1 | |
| SCHEMBL191884 | 0.67 | GRIN2D (0.41) | — | |
| SCHEMBL9799212 | 0.67 | NPC1 (0.33) | NPC1ALDH1A1 | |
| SCHEMBL3068629 | 0.66 | KMT2A (0.31) | ALDH1A1KMT2A | |
| SCHEMBL9298866 | 0.66 | MEN1 (0.35) | MEN1KMT2A | |
| SCHEMBL20042215 | 0.65 | SMN1; SMN2 (0.34) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150191468-A1 | INHIBITORS OF INFLUENZA VIRUSES REPLICATION | VERTEX PHARMACEUTICALS INCORPORATED | 2015-07-09 | — | — | US | disclosed |
| US-9051319-B2 | Inhibitors of influenza viruses replication | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2015-06-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150191468-A1 | INHIBITORS OF INFLUENZA VIRUSES REPLICATION | ACE, RNASEH1, ACE2 | NPC1 1578/4885ALDH1A1 3087/4885EPHX2 4389/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.