Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 13/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | PGK1 | P00558 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1838731 | 0.88 | PTGDR2 (0.41) | PTGDR2POLBMEN1KMT2ACYP2C9 | |
| SCHEMBL4878167 | 0.79 | MAPT (0.53) | PTGDR2POLBMEN1KMT2ACYP2C9 | |
| SCHEMBL23266142 | 0.77 | ALDH1A1 (0.47) | PTGDR2MEN1KMT2ACYP2C9LMNA | |
| SCHEMBL22075510 | 0.76 | PGK1 (0.38) | PTGDR2CYP2C9ALDH1A1PGK1 | |
| SCHEMBL6253178 | 0.75 | EGFR (0.47) | POLBCYP2C9LMNAALDH1A1 | |
| SCHEMBL9083244 | 0.75 | PGK1 (0.46) | CYP2C9ALDH1A1PGK1 | |
| SCHEMBL4861567 | 0.73 | ATM (0.47) | MEN1KMT2ALMNAALDH1A1 | |
| SCHEMBL22075488 | 0.72 | PGK1 (0.38) | CYP2C9ALDH1A1PGK1 | |
| SCHEMBL3041368 | 0.72 | PTGDR2 (0.47) | PTGDR2MEN1KMT2ACYP2C9ALDH1A1 | |
| SCHEMBL16792065 | 0.71 | PTGDR2 (0.46) | PTGDR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3080132-A1 | BROMODOMAIN INHIBITORS | AbbVie Inc. (US) | 2016-10-19 | — | — | EP | disclosed |
| WO-2015085925-A1 | BROMODOMAIN INHIBITORS | ABBVIE INC. (US) | 2015-06-18 | — | — | WO | disclosed |