Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.38 |
| ▸ | PGK1 | P00558 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.35 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16791726 | 0.88 | PTGDR2 (0.50) | PTGDR2POLBPGK1MEN1KMT2A | |
| SCHEMBL4861567 | 0.83 | ATM (0.47) | MEN1KMT2AALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL9083244 | 0.78 | PGK1 (0.46) | PGK1ALDH1A1KDM4ECYP1A2CYP3A4 | |
| SCHEMBL23266142 | 0.77 | ALDH1A1 (0.47) | PTGDR2MEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL22075488 | 0.76 | PGK1 (0.38) | PGK1ALDH1A1KDM4ECYP1A2CYP3A4 | |
| SCHEMBL22075510 | 0.72 | PGK1 (0.38) | PTGDR2PGK1ALDH1A1KDM4ECYP1A2 | |
| SCHEMBL17577280 | 0.72 | TRPV4 (0.41) | PTGDR2POLBTRPV4MEN1KMT2A | |
| SCHEMBL17577284 | 0.72 | TRPV4 (0.41) | PTGDR2TRPV4MEN1KMT2AALDH1A1 | |
| SCHEMBL31180206 | 0.72 | PGK1 (0.44) | POLBPGK1MEN1KMT2AALDH1A1 | |
| SCHEMBL16791990 | 0.72 | CYP2A6 (0.50) | ALDH1A1KDM4ECYP1A2CYP3A4MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8263656-B2 | Substituted aminotetralines | HOFFMANN-LA ROCHE INC. (US) | 2012-09-11 | — | — | US | disclosed |
| US-8263656-B2 | Substituted aminotetralines | HOFFMANN-LA ROCHE INC. (US) | 2012-09-11 | — | — | US | disclosed |
| EP-2321266-A2 | SUBSTITUTED AMINOTETRALINES | F. Hoffmann-La Roche AG (CH) | 2011-05-18 | — | — | EP | disclosed |
| WO-2010018109-A2 | SUBSTITUTED AMINOTETRALINES | F. HOFFMANN-LA ROCHE AG (CH) | 2010-02-18 | — | — | WO | disclosed |
| US-20100041713-A1 | SUBSTITUTED AMINOTETRALINES | FIROOZNIA FARIBORZ | 2010-02-18 | — | — | US | disclosed |
| US-20100041713-A1 | SUBSTITUTED AMINOTETRALINES | FIROOZNIA FARIBORZ | 2010-02-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100041713-A1 | SUBSTITUTED AMINOTETRALINES | HRH4, HRH1, HRH2 | PTGDR2 123/4885POLB 4366/4885TRPV4 1078/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.