Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 17/20 | 0.46 |
| ▸ | EPAS1 | Q99814 | 2/20 | 0.35 |
| ▸ | TTR | P02766 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16791848 | 0.77 | EPAS1 (0.39) | PTGDR2EPAS1TTR | |
| SCHEMBL16791849 | 0.76 | EPAS1 (0.41) | PTGDR2EPAS1TTR | |
| SCHEMBL16791726 | 0.71 | PTGDR2 (0.50) | PTGDR2 | |
| SCHEMBL22075510 | 0.70 | PGK1 (0.38) | PTGDR2 | |
| SCHEMBL22075488 | 0.67 | PGK1 (0.38) | — | |
| SCHEMBL21191011 | 0.67 | BRD4 (0.48) | EPAS1TTR | |
| SCHEMBL30443821 | 0.66 | EPAS1 (0.55) | EPAS1 | |
| SCHEMBL15067636 | 0.66 | EPAS1 (0.55) | EPAS1 | |
| SCHEMBL1838731 | 0.66 | PTGDR2 (0.41) | PTGDR2 | |
| SCHEMBL21190854 | 0.65 | BRD4 (0.50) | EPAS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3080132-A1 | BROMODOMAIN INHIBITORS | AbbVie Inc. (US) | 2016-10-19 | — | — | EP | disclosed |
| WO-2015085925-A1 | BROMODOMAIN INHIBITORS | ABBVIE INC. (US) | 2015-06-18 | — | — | WO | disclosed |