Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPAS1 | Q99814 | 4/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.37 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.36 |
| ▸ | PTGES2 | Q9H7Z7 | 1/20 | 0.35 |
| ▸ | TTR | P02766 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 2/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16792043 | 0.78 | BRD4 (0.47) | — | |
| SCHEMBL16791849 | 0.78 | EPAS1 (0.41) | EPAS1SLC6A2SLC6A4SLC6A3PTGDR2 | |
| SCHEMBL16792065 | 0.77 | PTGDR2 (0.46) | EPAS1PTGDR2TTR | |
| SCHEMBL16791808 | 0.70 | POLB (0.43) | SLC6A2SLC6A4SLC6A3SMN1; SMN2CA2 | |
| SCHEMBL21191011 | 0.68 | BRD4 (0.48) | EPAS1TTRSMN1; SMN2CA2 | |
| SCHEMBL15067636 | 0.68 | EPAS1 (0.55) | EPAS1 | |
| SCHEMBL30443821 | 0.68 | EPAS1 (0.55) | EPAS1 | |
| SCHEMBL21190854 | 0.66 | BRD4 (0.50) | EPAS1SLC6A4CA2CA1CA9 | |
| SCHEMBL16658442 | 0.66 | MAPT (0.43) | SMN1; SMN2 | |
| SCHEMBL30812017 | 0.66 | THRA (0.46) | EPAS1TTR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3080132-A1 | BROMODOMAIN INHIBITORS | AbbVie Inc. (US) | 2016-10-19 | — | — | EP | disclosed |
| WO-2015085925-A1 | BROMODOMAIN INHIBITORS | ABBVIE INC. (US) | 2015-06-18 | — | — | WO | disclosed |