Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TPH1 | P17752 | 2/20 | 0.47 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.41 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.40 |
| ▸ | CARM1 | Q86X55 | 2/20 | 0.40 |
| ▸ | PRMT1 | Q99873 | 2/20 | 0.40 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
| ▸ | HTR2B | P41595 | 1/20 | 0.38 |
| ▸ | LOX | P28300 | 1/20 | 0.36 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | XBP1 | P17861 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16814974 | 0.97 | TPH1 (0.47) | TPH1MCHR1CSNK2A1CARM1PRMT1 | |
| SCHEMBL16814978 | 0.90 | NCF1 (0.42) | TPH1CARM1PRMT1KEAP1KDM4E | |
| SCHEMBL16814975 | 0.90 | TPH1 (0.41) | TPH1CSNK2A1KEAP1HTR2CHTR2B | |
| SCHEMBL16814969 | 0.81 | GAA (0.47) | TPH1KEAP1L3MBTL1KDM4ECYP2C19 | |
| SCHEMBL23708614 | 0.79 | L3MBTL1 (0.46) | MCHR1KEAP1HTR2CHTR2BL3MBTL1 | |
| SCHEMBL16793146 | 0.78 | CSNK2A1 (0.44) | MCHR1CSNK2A1CARM1PRMT1 | |
| SCHEMBL16793203 | 0.77 | ALDH1A1 (0.46) | TPH1KEAP1L3MBTL1KDM4EMEN1 | |
| SCHEMBL16814987 | 0.77 | DPP4 (0.53) | TPH1KEAP1L3MBTL1MEN1KMT2A | |
| SCHEMBL16561643 | 0.77 | DPP4 (0.53) | TPH1KEAP1L3MBTL1MEN1KMT2A | |
| SCHEMBL16792915 | 0.76 | TPH1 (0.47) | TPH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015089137-A1 | ACYLGUANIDINES AS TRYPTOPHAN HYDROXYLASE INHIBITORS | KAROS PHARMACEUTICALS, INC. (US) | 2015-06-18 | — | — | WO | disclosed |
| WO-2015089137-A1 | ACYLGUANIDINES AS TRYPTOPHAN HYDROXYLASE INHIBITORS | KAROS PHARMACEUTICALS, INC. (US) | 2015-06-18 | — | — | WO | disclosed |