Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.43 |
| ▸ | FAAH | O00519 | 2/20 | 0.43 |
| ▸ | EEF2K | O00418 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | CHKA | P35790 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20570029 | 0.94 | ATM (0.47) | PKMNPSR1ATMFAAHL3MBTL1 | |
| SCHEMBL2932454 | 0.85 | L3MBTL1 (0.54) | PKMNPSR1ATMFAAHL3MBTL1 | |
| SCHEMBL5571317 | 0.84 | LMNA (0.46) | FAAHL3MBTL1HRH3MEN1LMNA | |
| SCHEMBL15265471 | 0.79 | GPR183 (0.50) | PKMNPSR1ATMFAAHL3MBTL1 | |
| SCHEMBL15265427 | 0.78 | HTR7 (0.46) | PKMNPSR1ATMFAAHL3MBTL1 | |
| SCHEMBL16795334 | 0.77 | KDM4E (0.47) | NPSR1FAAHL3MBTL1MEN1LMNA | |
| SCHEMBL20567070 | 0.75 | VEGFA (0.53) | NPSR1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL16795444 | 0.75 | GRIN2B (0.38) | PKMNPSR1GRIN2BHSD11B1EEF2K | |
| SCHEMBL2931705 | 0.75 | AKR1C3 (0.65) | FAAHHRH3MEN1LMNAKMT2A | |
| SCHEMBL4158729 | 0.75 | CA12 (0.60) | FAAHL3MBTL1HRH3MEN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015086693-A1 | PYRAZOLOPYRIMIDIN-2-YL DERIVATIVES AS JAK INHIBITORS | ALMIRALL, S.A. (ES) | 2015-06-18 | — | — | WO | disclosed |