Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | FAAH | O00519 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 4/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | HPGD | P15428 | 3/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | GPR183 | P32249 | 4/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | HBB | P68871 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.41 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.41 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5571317 | 0.89 | LMNA (0.46) | KDM4EFAAHLMNAALDH1A1HPGD | |
| SCHEMBL15265471 | 0.84 | GPR183 (0.50) | KDM4EFAAHLMNAALDH1A1HPGD | |
| SCHEMBL20570029 | 0.82 | ATM (0.47) | KDM4EFAAHLMNAALDH1A1HTT | |
| SCHEMBL18305752 | 0.80 | TDP1 (0.50) | KDM4ELMNAALDH1A1MEN1KMT2A | |
| SCHEMBL3047497 | 0.79 | KDM4E (0.71) | KDM4EFAAHLMNAALDH1A1HPGD | |
| SCHEMBL23111591 | 0.78 | USP2 (0.51) | FAAHALDH1A1HPGDTSHRL3MBTL1 | |
| SCHEMBL15224432 | 0.78 | KDM4E (0.51) | KDM4EFAAHLMNAALDH1A1HPGD | |
| SCHEMBL3617972 | 0.78 | ALDH1A1 (0.68) | KDM4EFAAHLMNAALDH1A1HPGD | |
| SCHEMBL2932454 | 0.78 | L3MBTL1 (0.54) | KDM4EFAAHLMNAALDH1A1HTT | |
| SCHEMBL16795240 | 0.77 | PKM (0.53) | FAAHLMNANPSR1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015086693-A1 | PYRAZOLOPYRIMIDIN-2-YL DERIVATIVES AS JAK INHIBITORS | ALMIRALL, S.A. (ES) | 2015-06-18 | — | — | WO | disclosed |