Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 6/20 | 0.65 |
| ▸ | ADRB1 | P08588 | 4/20 | 0.56 |
| ▸ | PLD1 | Q13393 | 2/20 | 0.53 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.53 |
| ▸ | NCF1 | P14598 | 1/20 | 0.53 |
| ▸ | CASP1 | P29466 | 1/20 | 0.53 |
| ▸ | CASP4 | P49662 | 1/20 | 0.53 |
| ▸ | CASP5 | P51878 | 1/20 | 0.53 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.50 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.50 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.50 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.49 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.48 |
| ▸ | CHRNB2 | P17787 | 3/20 | 0.46 |
| ▸ | CHRNA4 | P43681 | 3/20 | 0.46 |
| ▸ | HTR1A | P08908 | 1/20 | 0.46 |
| ▸ | HTR7 | P34969 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11857702 | 0.86 | ADRB1 (0.52) | HRH4ADRB1PLD1ADRB2NCF1 | |
| SCHEMBL11846373 | 0.86 | ADRB1 (0.52) | HRH4ADRB1PLD1ADRB2NCF1 | |
| SCHEMBL15445062 | 0.80 | ADRB2 (0.62) | HRH4ADRB1PLD1ADRB2NCF1 | |
| SCHEMBL12685317 | 0.78 | KARS1 (0.60) | HRH4ADRB1PLD1CASP1CASP4 | |
| SCHEMBL22988893 | 0.78 | CHRNB2 (0.51) | HRH4PLD1ADRB2NCF1HRH3 | |
| SCHEMBL27919283 | 0.77 | PLD1 (0.46) | HRH4ADRB1PLD1ADRB2NCF1 | |
| Hydrochloric Acid SCHEMBL15286384 | 0.76 | KARS1 (0.58) | HRH4ADRB1PLD1CASP1CASP4 | |
| SCHEMBL1026043 | 0.76 | ADRB1 (0.59) | ADRB1PLD1NCF1HRH3DYRK1A | |
| SCHEMBL6643085 | 0.76 | ADRB2 (0.56) | HRH4ADRB1PLD1ADRB2NCF1 | |
| SCHEMBL22581914 | 0.76 | ADRB1 (0.64) | ADRB1PLD1ADRB2NCF1CASP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015086693-A1 | PYRAZOLOPYRIMIDIN-2-YL DERIVATIVES AS JAK INHIBITORS | ALMIRALL, S.A. (ES) | 2015-06-18 | — | — | WO | disclosed |