Known targets — ChEMBL curated mechanism
MMP1MMP13MMP7MMP8polrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of (Z)-1,2-Diphenylethene. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.56 |
| ▸ | RELA | Q04206 | 2/20 | 0.56 |
| ▸ | MAOB | P27338 | 2/20 | 0.52 |
| ▸ | CHAT | P28329 | 2/20 | 0.52 |
| ▸ | TTR | P02766 | 1/20 | 0.52 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.52 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.52 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.52 |
| ▸ | TRPA1 | O75762 | 3/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | GLA | P06280 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.50 |
| ▸ | MAOA | P21397 | 1/20 | 0.50 |
| ▸ | GRM5 | P41594 | 1/20 | 0.48 |
| ▸ | PAM | P19021 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| (Z)-1,2-Diphenylethene SCHEMBL5575127 | 0.90 | RELA (0.52) | NFE2L2RELAMAOBCHATTTR | |
| (Z)-1,2-Diphenylethene SCHEMBL5576205 | 0.90 | RELA (0.52) | NFE2L2RELAMAOBCHATTTR | |
| (Z)-1,2-Diphenylethene SCHEMBL5575129 | 0.90 | RELA (0.52) | NFE2L2RELAMAOBCHATTTR | |
| (Z)-1,2-Diphenylethene SCHEMBL27870109 | 0.86 | MAOB (0.55) | NFE2L2RELAMAOBCHATTTR | |
| (Z)-1,2-Diphenylethene SCHEMBL2067523 | 0.86 | MAOB (0.55) | NFE2L2RELAMAOBCHATTTR | |
| Alcohol SCHEMBL27277633 | 0.85 | NPC1 (0.44) | NFE2L2RELAMAOBCHATTTR | |
| Cinnamic Alcohol SCHEMBL901221 | 0.85 | PAM (0.52) | NFE2L2RELAMAOBNPC1L3MBTL1 | |
| Cinnamic Alcohol SCHEMBL28289701 | 0.85 | PAM (0.52) | NFE2L2RELAMAOBNPC1L3MBTL1 | |
| (Z)-1,2-Diphenylethene SCHEMBL29134000 | 0.85 | MAOB (0.69) | NFE2L2RELAMAOBCHATTTR | |
| (Z)-1,2-Diphenylethene SCHEMBL28291545 | 0.82 | MAOB (0.65) | NFE2L2RELAMAOBCHATTTR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 33 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104706708-B | Red stilbene ethanol extract prevents and treats application and wherein effective component identification method in hepatic fibrosis medicines in preparation | 兰州大学 | 2018-11-20 | — | — | CN | claimed |
| EP-0491831-A4 | — | — | 1994-01-05 | — | — | EP | claimed |
| EP-0491831-A1 | PROCESS FOR THE PRODUCTION OF ESTERS EXHIBITING NONLINEAR OPTICAL RESPONSE | HOECHST CELANESE CORPORATION (US) | 1992-07-01 | — | — | EP | claimed |
| WO-1991003457-A1 | PROCESS FOR THE PRODUCTION OF ESTERS EXHIBITING NONLINEAR OPTICAL RESPONSE | HOECHST CELANESE CORPORATION (US) | 1991-03-21 | — | — | WO | claimed |
| US-4997977-A | Process for the production of esters exhibiting nonlinear optical response | HOECHST CELANESE CORP. (US) | 1991-03-05 | — | — | US | claimed |
| CN-110204588-A | A method of preparing Astragaloside IV | 劲牌有限公司 | 2019-09-06 | — | — | CN | disclosed |
| CN-110063428-A | Application and preparation method thereof of the Astragalus Root P.E in preparation fresh-water fishes Antistress agent | 内江师范学院 | 2019-07-30 | — | — | CN | disclosed |
| CN-109975166-A | A kind of improved method of hot dipping measurement Chinese herbal medicine extract | 甘肃农业大学 | 2019-07-05 | — | — | CN | disclosed |
| CN-109085257-A | A kind of method that simultaneous quantitative detects Astragaloside IV-IV, cycloastragenol in mice plasma | 中央民族大学 | 2018-12-25 | — | — | CN | disclosed |
| CN-104706708-B | Red stilbene ethanol extract prevents and treats application and wherein effective component identification method in hepatic fibrosis medicines in preparation | 兰州大学 | 2018-11-20 | — | — | CN | disclosed |
| CN-104706708-B | Red stilbene ethanol extract prevents and treats application and wherein effective component identification method in hepatic fibrosis medicines in preparation | 兰州大学 | 2018-11-20 | — | — | CN | disclosed |
| CN-104706708-B | Red stilbene ethanol extract prevents and treats application and wherein effective component identification method in hepatic fibrosis medicines in preparation | 兰州大学 | 2018-11-20 | — | — | CN | disclosed |
| EP-0491831-A1 | PROCESS FOR THE PRODUCTION OF ESTERS EXHIBITING NONLINEAR OPTICAL RESPONSE | HOECHST CELANESE CORPORATION (US) | 1992-07-01 | — | — | EP | disclosed |
| US-5044725-A | Polymeric thin film waveguide media | HOECHST CELANESE CORP. (US) | 1991-09-03 | — | — | US | disclosed |
| US-5002361-A | Polymeric thin film waveguide media | HOECHST CELANESE CORP. (US) | 1991-03-26 | — | — | US | disclosed |
| WO-1991003683-A1 | ACRYLIC COPOLYMERS EXHIBITING NONLINEAR OPTICAL RESPONSE | HOECHST CELANESE CORP (US) | 1991-03-21 | — | — | WO | disclosed |
| WO-1991003457-A1 | PROCESS FOR THE PRODUCTION OF ESTERS EXHIBITING NONLINEAR OPTICAL RESPONSE | HOECHST CELANESE CORPORATION (US) | 1991-03-21 | — | — | WO | disclosed |
| WO-1991003457-A1 | PROCESS FOR THE PRODUCTION OF ESTERS EXHIBITING NONLINEAR OPTICAL RESPONSE | HOECHST CELANESE CORPORATION (US) | 1991-03-21 | — | — | WO | disclosed |
| US-4997977-A | Process for the production of esters exhibiting nonlinear optical response | HOECHST CELANESE CORP. (US) | 1991-03-05 | — | — | US | disclosed |
| US-4997977-A | Process for the production of esters exhibiting nonlinear optical response | HOECHST CELANESE CORP. (US) | 1991-03-05 | — | — | US | disclosed |