Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.55 |
| ▸ | RORC | P51449 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | IDO1 | P14902 | 1/20 | 0.42 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.42 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14546864 | 0.80 | SMN1; SMN2 (0.71) | SMN1; SMN2HPGDALDH1A1KMT2AMEN1 | |
| SCHEMBL17114519 | 0.79 | RORC (0.78) | RORC | |
| SCHEMBL2079112 | 0.79 | SMN1; SMN2 (0.54) | SMN1; SMN2RORCHPGDALDH1A1KMT2A | |
| SCHEMBL18275088 | 0.78 | SRD5A2 (0.45) | ALDH1A1KMT2AMEN1LMNACYP1A2 | |
| SCHEMBL20709290 | 0.75 | RORC (0.43) | SMN1; SMN2RORCHPGDALDH1A1KMT2A | |
| SCHEMBL18151593 | 0.73 | MAPT (0.39) | RORCHPGDALDH1A1KMT2AMEN1 | |
| SCHEMBL5544653 | 0.73 | SMN1; SMN2 (0.71) | SMN1; SMN2HPGDALDH1A1KMT2AMEN1 | |
| SCHEMBL28028708 | 0.73 | SMN1; SMN2 (0.71) | SMN1; SMN2HPGDALDH1A1KMT2AMEN1 | |
| SCHEMBL9784355 | 0.73 | SMN1; SMN2 (0.71) | SMN1; SMN2HPGDALDH1A1KMT2AMEN1 | |
| SCHEMBL669442 | 0.72 | EPHX2 (0.70) | SMN1; SMN2ALDH1A1KMT2AMEN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3077372-A1 | ROR GAMMA (RORY) MODULATORS | Lead Pharma Cel Models IP B.V. (NL) | 2016-10-12 | — | — | EP | claimed |
| WO-2015082533-A1 | ROR GAMMA (RORY) MODULATORS | LEAD PHARMA CEL MODELS IP B.V. (NL) | 2015-06-11 | — | — | WO | claimed |