Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | RORC | P51449 | 2/20 | 0.32 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.31 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16800949 | 0.86 | GRM5 (0.36) | GRM5ALDH1A1LMNARORC | |
| SCHEMBL16798942 | 0.86 | GRM5 (0.37) | GRM5L3MBTL1MAPTALDH1A1RORC | |
| SCHEMBL16800677 | 0.84 | SMN1; SMN2 (0.41) | L3MBTL1MAPTALDH1A1LMNANPC1 | |
| SCHEMBL16799547 | 0.84 | GRM5 (0.36) | GRM5 | |
| SCHEMBL16801068 | 0.83 | GRM5 (0.45) | GRM5MAPTALDH1A1RORCCYP11B2 | |
| SCHEMBL16800859 | 0.82 | GRM5 (0.33) | GRM5CYP11B2 | |
| SCHEMBL16800681 | 0.81 | MAPT (0.38) | GRM5MAPTALDH1A1LMNANPC1 | |
| SCHEMBL16799448 | 0.81 | CYP11B2 (0.40) | GRM5CYP11B2NPC1RAB9A | |
| SCHEMBL16800806 | 0.81 | CYP11B2 (0.36) | GRM5CYP11B2 | |
| SCHEMBL18248717 | 0.80 | GRM5 (0.33) | GRM5RORC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015083130-A1 | FUSED PYRIDINE AND PYRIMIDINE DERIVATIVES AS ROR GAMMA MODULATORS | AURIGENE DISCOVERY TECHNOLOGIES LIMITED (IN) | 2015-06-11 | — | — | WO | disclosed |
| WO-2015083130-A1 | FUSED PYRIDINE AND PYRIMIDINE DERIVATIVES AS ROR GAMMA MODULATORS | AURIGENE DISCOVERY TECHNOLOGIES LIMITED (IN) | 2015-06-11 | — | — | WO | disclosed |