Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 4/20 | 0.44 |
| ▸ | ALB | P02768 | 2/20 | 0.41 |
| ▸ | P2RX7 | Q99572 | 3/20 | 0.40 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | DPP4 | P27487 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | CASP1 | P29466 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16799127 | 0.81 | NPC1 (0.42) | GRM5ALBALOX5MEN1KMT2A | |
| SCHEMBL16799611 | 0.81 | GRM4 (0.45) | ALBP2RX7ALOX5MEN1KMT2A | |
| SCHEMBL3371217 | 0.73 | GRM5 (0.59) | GRM5MEN1KMT2A | |
| SCHEMBL16879999 | 0.73 | DRD2 (0.42) | GRM5ALBALOX5MEN1KMT2A | |
| SCHEMBL3406745 | 0.72 | GRM5 (0.50) | GRM5MEN1KMT2AL3MBTL1 | |
| SCHEMBL3051636 | 0.72 | ESR1 (0.52) | P2RX7MAPT | |
| SCHEMBL1037551 | 0.71 | GRM5 (0.32) | GRM5 | |
| SCHEMBL16799021 | 0.70 | ADRB1 (0.40) | MEN1KMT2AALDH1A1MAPT | |
| SCHEMBL3398754 | 0.70 | GRM5 (0.38) | GRM5 | |
| SCHEMBL3371568 | 0.70 | GRM5 (0.41) | GRM5MEN1KMT2APOLBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015083130-A1 | FUSED PYRIDINE AND PYRIMIDINE DERIVATIVES AS ROR GAMMA MODULATORS | AURIGENE DISCOVERY TECHNOLOGIES LIMITED (IN) | 2015-06-11 | — | — | WO | disclosed |
| WO-2015083130-A1 | FUSED PYRIDINE AND PYRIMIDINE DERIVATIVES AS ROR GAMMA MODULATORS | AURIGENE DISCOVERY TECHNOLOGIES LIMITED (IN) | 2015-06-11 | — | — | WO | disclosed |