Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | JAK1 | P23458 | 1/20 | 0.34 |
| ▸ | TYK2 | P29597 | 1/20 | 0.34 |
| ▸ | JAK3 | P52333 | 1/20 | 0.34 |
| ▸ | HTR3A | P46098 | 1/20 | 0.33 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26131630 | 0.94 | HTR3A (0.40) | JAK2JAK1TYK2JAK3HTR3A | |
| SCHEMBL15008660 | 0.92 | — | — | |
| SCHEMBL22121629 | 0.85 | GBA1 (0.42) | HRH4 | |
| SCHEMBL20535826 | 0.84 | MAPK1 (0.33) | — | |
| SCHEMBL20535685 | 0.78 | MCHR1 (0.34) | — | |
| SCHEMBL20599456 | 0.67 | ALDH1A1 (0.31) | — | |
| SCHEMBL7854040 | 0.65 | — | — | |
| SCHEMBL27634624 | 0.63 | HRH4 (0.34) | JAK2JAK1TYK2JAK3HTR3A | |
| SCHEMBL26129989 | 0.62 | GRIN2D (0.32) | — | |
| SCHEMBL21384244 | 0.61 | CACNA1H (0.31) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3077387-A1 | BENZAMIDE DERIVATIVE USEFUL AS FASN INHIBITORS FOR THE TREATMENT OF CANCER | Janssen Pharmaceutica, N.V. (BE) | 2016-10-12 | — | — | EP | claimed |
| WO-2015084606-A1 | BENZAMIDE DERIVATIVE USEFUL AS FASN INHIBITORS FOR THE TREATMENT OF CANCER | JANSSEN PHARMACEUTICA NV (BE) | 2015-06-11 | — | — | WO | claimed |