Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.66 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.56 |
| ▸ | NPC1 | O15118 | 4/20 | 0.54 |
| ▸ | RAB9A | P51151 | 4/20 | 0.54 |
| ▸ | MAPT | P10636 | 3/20 | 0.54 |
| ▸ | POLB | P06746 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.54 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.54 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.49 |
| ▸ | PDK1 | Q15118 | 2/20 | 0.49 |
| ▸ | PDK2 | Q15119 | 2/20 | 0.49 |
| ▸ | PDK3 | Q15120 | 2/20 | 0.49 |
| ▸ | PDK4 | Q16654 | 2/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL812759 | 0.83 | NAPRT (0.64) | SMN1; SMN2NAPRTHSD17B10NPC1RAB9A | |
| SCHEMBL18275167 | 0.81 | ALDH1A1 (0.50) | SMN1; SMN2NPC1RAB9AALDH1A1MAPK1 | |
| SCHEMBL2081375 | 0.80 | SMN1; SMN2 (1.00) | SMN1; SMN2L3MBTL1MAPK1HTTRORC | |
| SCHEMBL21047664 | 0.78 | SMN1; SMN2 (0.72) | SMN1; SMN2NAPRTHSD17B10RAB9AMAPT | |
| SCHEMBL9784355 | 0.78 | SMN1; SMN2 (0.71) | SMN1; SMN2NAPRTHSD17B10NPC1RAB9A | |
| SCHEMBL14546864 | 0.78 | SMN1; SMN2 (0.71) | SMN1; SMN2NAPRTHSD17B10RAB9AMAPT | |
| SCHEMBL28028708 | 0.78 | SMN1; SMN2 (0.71) | SMN1; SMN2NAPRTHSD17B10NPC1RAB9A | |
| SCHEMBL5544653 | 0.78 | SMN1; SMN2 (0.71) | SMN1; SMN2NAPRTHSD17B10NPC1RAB9A | |
| SCHEMBL669442 | 0.77 | EPHX2 (0.70) | SMN1; SMN2NPC1RAB9AMAPTKMT2A | |
| SCHEMBL27965790 | 0.77 | NAPRT (0.60) | SMN1; SMN2NAPRTHSD17B10NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3077372-A1 | ROR GAMMA (RORY) MODULATORS | Lead Pharma Cel Models IP B.V. (NL) | 2016-10-12 | — | — | EP | claimed |
| WO-2015082533-A1 | ROR GAMMA (RORY) MODULATORS | LEAD PHARMA CEL MODELS IP B.V. (NL) | 2015-06-11 | — | — | WO | claimed |