SCHEMBL1680692

SCHEMBL1680692

N#Cc1cc(Oc2ccccc2)ccn1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 5/20 0.47
KMT2A Q03164 5/20 0.47
ALDH1A1 P00352 4/20 0.47
CYP1A2 P05177 1/20 0.47
CYP2C9 P11712 1/20 0.47
CYP2C19 P33261 1/20 0.47
L3MBTL1 Q9Y468 1/20 0.47
HPGD P15428 3/20 0.46
GLA P06280 1/20 0.46
POLB P06746 1/20 0.46
SMN1; SMN2 Q16637 1/20 0.46
ALOX5AP P20292 2/20 0.45
FEN1 P39748 2/20 0.45
KDR P35968 1/20 0.45
CYP19A1 P11511 3/20 0.44
LTA4H P09960 2/20 0.44
GCK P35557 1/20 0.43
TSHR P16473 1/20 0.43
ERBB2 P04626 1/20 0.43
NPC1 O15118 2/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29770616 1.00 MEN1 (0.47) MEN1KMT2AALDH1A1CYP1A2CYP2C9
SCHEMBL1642799 0.84 ALDH1A1 (0.48) MEN1KMT2AALDH1A1POLBSMN1; SMN2
SCHEMBL5318849 0.83 MAOB (0.51) MEN1KMT2AALDH1A1POLBSMN1; SMN2
SCHEMBL3539048 0.83 CYP19A1 (0.40) MEN1KMT2AALDH1A1SMN1; SMN2ALOX5AP
SCHEMBL2194408 0.83 CYP19A1 (0.66) ALDH1A1SMN1; SMN2CYP19A1LTA4H
SCHEMBL26036511 0.80 KDR (0.45) ALOX5APFEN1KDR
SCHEMBL1936332 0.80 POLB (0.49) ALDH1A1CYP1A2CYP2C9CYP2C19L3MBTL1
SCHEMBL24414328 0.79 MYC (0.46) MEN1KMT2AALDH1A1CYP1A2CYP2C9
SCHEMBL15915600 0.79 ALOX5AP (0.49) MEN1KMT2APOLBALOX5APFEN1
SCHEMBL12439723 0.78 MAOB (0.62) CYP1A2CYP2C19L3MBTL1SMN1; SMN2NPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 35 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4055021-B1 HETEROCYCLIC RIP1 INHIBITORY COMPOUNDS RIGEL PHARMACEUTICALS INC (US) 2025-10-08 EP disclosed
EP-4025568-B1 RIP1 INHIBITORY COMPOUNDS AND METHODS FOR MAKING AND USING THE SAME RIGEL PHARMACEUTICALS INC (US) 2025-05-14 EP disclosed
EP-4025574-B1 RIP1 INHIBITORY COMPOUNDS AND METHODS FOR MAKING AND USING THE SAME RIGEL PHARMACEUTICALS INC (US) 2025-05-07 EP disclosed
US-20250092057-A1 HETEROCYCLIC RIP1 INHIBITORY COMPOUNDS RIGEL PHARMACEUTICALS, INC. 2025-03-20 US disclosed
CN-115298184-B Heterocyclic RIP1 inhibiting compounds 里格尔药品股份有限公司 2025-01-28 CN disclosed
US-20240368119-A1 RIP1 INHIBITORY COMPOUNDS AND METHODS FOR MAKING AND USING THE SAME RIGEL PHARMACEUTICALS, INC. 2024-11-07 US disclosed
US-20230322732-A1 RIP1 Inhibitory Compounds and Methods for Making and Using the Same RIGEL PHARMACEUTICALS, INC. 2023-10-12 US disclosed
US-20230322732-A1 RIP1 Inhibitory Compounds and Methods for Making and Using the Same RIGEL PHARMACEUTICALS, INC. 2023-10-12 US disclosed
US-20230143161-A1 HETEROCYCLIC RIP1 INHIBITORY COMPOUNDS RIGEL PHARMACEUTICALS, INC. 2023-05-11 US disclosed
US-20230143161-A1 HETEROCYCLIC RIP1 INHIBITORY COMPOUNDS RIGEL PHARMACEUTICALS, INC. 2023-05-11 US disclosed
WO-2021046382-A1 RIP1 INHIBITORY COMPOUNDS AND METHODS FOR MAKING AND USING THE SAME RIGEL PHARMACEUTICALS, INC. (US) 2021-03-11 WO disclosed
WO-2021046382-A1 RIP1 INHIBITORY COMPOUNDS AND METHODS FOR MAKING AND USING THE SAME RIGEL PHARMACEUTICALS, INC. (US) 2021-03-11 WO disclosed
WO-2021046407-A1 RIP1 INHIBITORY COMPOUNDS AND METHODS FOR MAKING AND USING THE SAME RIGEL PHARMACEUTICALS, INC. (US) 2021-03-11 WO disclosed
WO-2021046407-A1 RIP1 INHIBITORY COMPOUNDS AND METHODS FOR MAKING AND USING THE SAME RIGEL PHARMACEUTICALS, INC. (US) 2021-03-11 WO disclosed
US-20110195999-A1 NOVEL ANTIFUNGAL AGENT CONTAINING HETEROCYCLIC COMPOUND NAKAMOTO KAZUTAKA 2011-08-11 US disclosed
US-7932272-B2 Antifungal agent containing heterocyclic compound EISAI R&D MANAGEMENT CO., LTD. (JP) 2011-04-26 US disclosed
US-20090227799-A1 Novel Antimalarial Agent Containing Heterocyclic Compound EISAI R&D MANAGEMENT CO., LTD. (JP) 2009-09-10 US disclosed
US-20070105943-A1 Novel antifungal agent containing heterocyclic compound EISAI R&D MANAGEMENT CO., LTD. (JP) 2007-05-10 US disclosed
EP-1782811-A1 NOVEL ANTIMALARIA AGENT CONTAINING HETEROCYCLIC COMPOUND Eisai R&D Management Co., Ltd. (JP) 2007-05-09 EP disclosed
EP-1669348-A1 NOVEL ANTIFUNGAL AGENT COMPRISING HETEROCYCLIC COMPOUND Eisai Co., Ltd. (JP) 2006-06-14 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230143161-A1 HETEROCYCLIC RIP1 INHIBITORY COMPOUNDS RIPK1, RIPK2, RIPK3 MEN1 2028/4885KMT2A 3657/4885ALDH1A1 4391/4885
US-20240368119-A1 RIP1 INHIBITORY COMPOUNDS AND METHODS FOR MAKING AND USING THE SAME RIPK1, RIPK2, RIPK3 MEN1 2540/4885KMT2A 3696/4885ALDH1A1 4505/4885
US-20110195999-A1 NOVEL ANTIFUNGAL AGENT CONTAINING HETEROCYCLIC COMPOUND ERG28, CYP51A1, XPO1 MEN1 351/4885KMT2A 3747/4885ALDH1A1 1677/4885
US-20090227799-A1 Novel Antimalarial Agent Containing Heterocyclic Compound XPO1, THPO, G6PD MEN1 1165/4885KMT2A 2620/4885ALDH1A1 1926/4885
US-20070105943-A1 Novel antifungal agent containing heterocyclic compound ERG28, DPM1, CYP51A1 MEN1 248/4885KMT2A 3740/4885ALDH1A1 1459/4885
US-20230322732-A1 RIP1 Inhibitory Compounds and Methods for Making and Using the Same RIPK1, RIPK2, RIPK3 MEN1 2540/4885KMT2A 3696/4885ALDH1A1 4505/4885
US-20250092057-A1 HETEROCYCLIC RIP1 INHIBITORY COMPOUNDS RIPK1, RIPK2, RIPK3 MEN1 2028/4885KMT2A 3657/4885ALDH1A1 4391/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.