Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 7/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.33 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.31 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13054412 | 0.81 | GABRA1 (0.35) | NOTUM | |
| SCHEMBL21866757 | 0.81 | CREBBP (0.32) | NOTUM | |
| SCHEMBL12533408 | 0.80 | PARP1 (0.31) | PARP1NOTUM | |
| SCHEMBL12407089 | 0.80 | GABRA1 (0.40) | NOTUM | |
| SCHEMBL10093043 | 0.77 | PARP1 (0.44) | PARP1HTR1ASLC6A4ALKNOTUM | |
| SCHEMBL4344995 | 0.77 | PARP1 (0.46) | PARP1HTR1ASLC6A4ALKNOTUM | |
| SCHEMBL12169271 | 0.77 | HTR2C (0.35) | HTR1A | |
| SCHEMBL10543708 | 0.75 | HTR1A (0.33) | PARP1HTR1ASLC6A4 | |
| SCHEMBL13533160 | 0.74 | P4HB (0.31) | PARP1 | |
| SCHEMBL6635190 | 0.74 | PARP1 (0.47) | PARP1HTR1ASLC6A4ALKNOTUM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9278975-B2 | Pyrazolo[1,5-A]pyrimidines as antiviral agents | GILEAD SCIENCES, INC. (US) | 2016-03-08 | — | — | US | disclosed |
| US-20150166546-A1 | PYRAZOLO[1,5-A]PYRIMIDINES AS ANTIVIRAL AGENTS | GILEAD SCIENCES, INC. | 2015-06-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150166546-A1 | PYRAZOLO[1,5-A]PYRIMIDINES AS ANTIVIRAL AGENTS | TYMP, ZC3HAV1, TYMS | PARP1 673/4885HTR1A 1821/4885SLC6A4 2636/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.