Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.40 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.40 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
| ▸ | HTR2B | P41595 | 1/20 | 0.39 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.39 |
| ▸ | CRHBP | P24387 | 1/20 | 0.38 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | GFER | P55789 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 2/20 | 0.38 |
| ▸ | BRPF1 | P55201 | 2/20 | 0.38 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.37 |
| ▸ | SMARCA2 | P51531 | 2/20 | 0.37 |
| ▸ | SMARCA4 | P51532 | 2/20 | 0.37 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16792864 | 0.99 | MAPT (0.43) | MAPTLMNAHIF1AKMT2AS1PR1 | |
| SCHEMBL26288600 | 0.81 | KMT2A (0.51) | MAPTLMNAHIF1AKMT2AS1PR1 | |
| SCHEMBL16814969 | 0.81 | GAA (0.47) | MAPTLMNAKMT2ASMN1; SMN2GFER | |
| SCHEMBL26288710 | 0.81 | KMT2A (0.51) | MAPTLMNAHIF1AKMT2AS1PR1 | |
| SCHEMBL16814984 | 0.75 | TPH1 (0.48) | MAPTLMNAKMT2ASMN1; SMN2GFER | |
| SCHEMBL4629735 | 0.74 | NCF1 (0.47) | LMNACHRM4HRH3SMN1; SMN2GFER | |
| SCHEMBL16814933 | 0.73 | MAPK1 (0.42) | MAPTLMNASMN1; SMN2 | |
| SCHEMBL16792819 | 0.73 | SMN1; SMN2 (0.42) | MAPTLMNAKMT2ASMN1; SMN2 | |
| SCHEMBL16792966 | 0.72 | TPH1 (0.47) | KMT2AHTR2CHTR2B | |
| SCHEMBL16814976 | 0.71 | TPH1 (0.48) | MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015089137-A1 | ACYLGUANIDINES AS TRYPTOPHAN HYDROXYLASE INHIBITORS | KAROS PHARMACEUTICALS, INC. (US) | 2015-06-18 | — | — | WO | disclosed |