Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 known ✓ | P08172 | 1/20 | 0.46 |
| ▸ | CHRM1 known ✓ | P11229 | 1/20 | 0.46 |
| ▸ | CHRM3 known ✓ | P20309 | 1/20 | 0.46 |
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.46 |
| ▸ | SLC6A3 known ✓ | Q01959 | 1/20 | 0.46 |
| ▸ | DNM1 | Q05193 | 8/20 | 0.62 |
| ▸ | HTT | P42858 | 3/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | THRB | P10828 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 1/20 | 0.57 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.47 |
| ▸ | RAD52 | P43351 | 2/20 | 0.47 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.47 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.47 |
| ▸ | MLNR | O43193 | 1/20 | 0.46 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.46 |
| ▸ | ESR1 | P03372 | 1/20 | 0.46 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL1683346 | 1.00 | DNM1 (0.62) | DNM1HTTKMT2AMEN1THRB | |
| Hydrochloric Acid SCHEMBL4805429 | 1.00 | DNM1 (0.62) | DNM1HTTKMT2AMEN1THRB | |
| Hydrochloric Acid SCHEMBL5552101 | 1.00 | DNM1 (0.62) | DNM1HTTKMT2AMEN1THRB | |
| SCHEMBL7091336 | 0.98 | DNM1 (0.64) | DNM1HTTKMT2AMEN1THRB | |
| SCHEMBL7089797 | 0.98 | DNM1 (0.64) | DNM1HTTKMT2AMEN1THRB | |
| SCHEMBL4808190 | 0.98 | DNM1 (0.64) | DNM1HTTKMT2AMEN1THRB | |
| Hydrochloric Acid SCHEMBL7940293 | 0.90 | HTT (0.68) | DNM1HTTKMT2AHSP90AA1RAD52 | |
| Hydrochloric Acid SCHEMBL4801453 | 0.89 | DNM1 (0.50) | DNM1HTTKMT2AMEN1THRB | |
| SCHEMBL25834238 | 0.89 | DNM1 (0.61) | DNM1HTTKMT2AMEN1THRB | |
| SCHEMBL31347471 | 0.88 | HTT (0.71) | DNM1HTTKMT2AHSP90AA1RAD52 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110124772-A1 | ANTIMICROBIAL POLYMERS AND THEIR USES | DSM IP ASSETS B.V. (NL) | 2011-05-26 | — | — | US | disclosed |
| EP-2309851-A2 | ANTIMICROBIAL POLYMERS AND THEIR USES | DSM IP Assets B.V. (NL) | 2011-04-20 | — | — | EP | disclosed |
| WO-2009148880-A2 | ANTIMICROBIAL POLYMERS AND THEIR USES | DSM IP ASSETS B.V. (NL) | 2009-12-10 | — | — | WO | disclosed |