Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 known ✓ | P08172 | 1/20 | 0.39 |
| ▸ | CHRM1 known ✓ | P11229 | 1/20 | 0.39 |
| ▸ | CHRM3 known ✓ | P20309 | 1/20 | 0.39 |
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.39 |
| ▸ | SLC6A3 known ✓ | Q01959 | 1/20 | 0.39 |
| ▸ | DNM1 | Q05193 | 9/20 | 0.50 |
| ▸ | HTT | P42858 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | MLNR | O43193 | 1/20 | 0.39 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.39 |
| ▸ | ESR1 | P03372 | 1/20 | 0.39 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.39 |
| ▸ | PGR | P06401 | 1/20 | 0.39 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.39 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL1683335 | 0.89 | DNM1 (0.62) | DNM1HTTMEN1THRBKMT2A | |
| Hydrochloric Acid SCHEMBL5552101 | 0.89 | DNM1 (0.62) | DNM1HTTMEN1THRBKMT2A | |
| Hydrochloric Acid SCHEMBL1683346 | 0.89 | DNM1 (0.62) | DNM1HTTMEN1THRBKMT2A | |
| Hydrochloric Acid SCHEMBL4805429 | 0.89 | DNM1 (0.62) | DNM1HTTMEN1THRBKMT2A | |
| SCHEMBL4808190 | 0.87 | DNM1 (0.64) | DNM1HTTMEN1THRBKMT2A | |
| SCHEMBL7091336 | 0.87 | DNM1 (0.64) | DNM1HTTMEN1THRBKMT2A | |
| SCHEMBL7089797 | 0.87 | DNM1 (0.64) | DNM1HTTMEN1THRBKMT2A | |
| Di(Hydroxyethyl)Ether SCHEMBL9818423 | 0.82 | DNM1 (0.64) | DNM1HTTMEN1THRBKMT2A | |
| Hydrochloric Acid SCHEMBL22206821 | 0.81 | DNM1 (0.67) | DNM1HTTKMT2ATSHRPLA2G1B | |
| Hydrochloric Acid SCHEMBL20550689 | 0.81 | DNM1 (0.67) | DNM1HTTKMT2ATSHRPLA2G1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8436083-B2 | Multifunctional self-decontaminating surface coating | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF THE NAVY (US) | 2013-05-07 | — | — | US | disclosed |
| US-20120172489-A1 | MULTIFUNCTIONAL SELF-DECONTAMINATING SURFACE COATING | THE GOVERNMENT OF THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF THE NAVY (US) | 2012-07-05 | — | — | US | disclosed |
| US-7452951-B2 | Multifunctional self-decontaminating surface coating | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE NAVY (US) | 2008-11-18 | — | — | US | disclosed |
| US-20080102281-A1 | MULTIFUNCTIONAL SELF-DECONTAMINATING SURFACE COATING | THE GOVERNMENT OF THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF THE NAVY (US) | 2008-05-01 | — | — | US | disclosed |
| US-7339015-B2 | Multifunctional self-decontaminating surface coating | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE NAVY (US) | 2008-03-04 | — | — | US | disclosed |
| US-20070122438-A1 | Multifunctional self-decontaminating surface coating | THE GOVERNMENT OF THE UNITED STATES, AS RESPRESENTED BY THE SECRETARY OF THE NAVY | 2007-05-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120172489-A1 | MULTIFUNCTIONAL SELF-DECONTAMINATING SURFACE COATING | YWHAZ, EPCAM, LBR | CHRM2 300/4885CHRM1 185/4885CHRM3 257/4885 |
| US-20070122438-A1 | Multifunctional self-decontaminating surface coating | YWHAZ, EPCAM, LBR | CHRM2 300/4885CHRM1 185/4885CHRM3 257/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.