Justicidin A

Justicidin A

SCHEMBL168356

COc1cc2c(OC)c3c(c(-c4ccc5c(c4)OCO5)c2cc1OC)C(=O)OC3

nearest known ligand 0.82

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.82
MAPT P10636 4/20 0.82
KDM4E B2RXH2 3/20 0.82
NPSR1 Q6W5P4 2/20 0.82
HPGD P15428 3/20 0.78
LMNA P02545 2/20 0.78
KMT2A Q03164 2/20 0.78
MEN1 O00255 1/20 0.78
HTT P42858 1/20 0.78
ALOX5 P09917 5/20 0.65
TOP2A P11388 1/20 0.54
SMN1; SMN2 Q16637 2/20 0.48
TP53 P04637 1/20 0.48
CYP3A4 P08684 1/20 0.48
HSD17B10 Q99714 1/20 0.48
L3MBTL1 Q9Y468 1/20 0.47
EDNRB P24530 4/20 0.47
EDNRA P25101 2/20 0.47
PDE1A P54750 2/20 0.46
PDE1B Q01064 2/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Justicidin A SCHEMBL30368670 1.00 ALDH1A1 (0.82) ALDH1A1MAPTKDM4ENPSR1HPGD
Justicidin A SCHEMBL29731045 1.00 ALDH1A1 (0.82) ALDH1A1MAPTKDM4ENPSR1HPGD
Taiwanin E Methyl Ether SCHEMBL30637589 0.95 MAPT (0.74) ALDH1A1MAPTKDM4ENPSR1HPGD
Taiwanin E Methyl Ether SCHEMBL11954034 0.95 MAPT (0.74) ALDH1A1MAPTKDM4ENPSR1HPGD
SCHEMBL18812556 0.93 MAPT (0.75) ALDH1A1MAPTKDM4ENPSR1HPGD
Chinensinaphthol Methyl Ether SCHEMBL30471940 0.92 KDM4E (0.70) ALDH1A1MAPTKDM4ENPSR1HPGD
Chinensinaphthol Methyl Ether SCHEMBL30471865 0.92 KDM4E (0.70) ALDH1A1MAPTKDM4ENPSR1HPGD
Neojusticin B SCHEMBL30190318 0.91 ALDH1A1 (0.72) ALDH1A1MAPTKDM4ENPSR1HPGD
Neojusticin B SCHEMBL30471811 0.91 ALDH1A1 (0.72) ALDH1A1MAPTKDM4ENPSR1HPGD
Neojusticin B SCHEMBL15920775 0.91 ALDH1A1 (0.72) ALDH1A1MAPTKDM4ENPSR1HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 811 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4674894-A2 COPOLYMERS OF N-VINYLPYRROLIDONE WITH FUNCTIONALIZED MALEIC ACID MOIETIES Hemoteq AG (DE) 2026-01-07 EP claimed
EP-4663688-A2 CROSSLINKERS Hemoteq AG (DE) 2025-12-17 EP claimed
US-11167065-B2 Shellac and paclitaxel coated catheter balloons EUROCOR TECH GMBH (DE) 2021-11-09 US claimed
US-10869904-B2 Pharmaceutical composition for preventing or treating respiratory disease comprising extract of Justicia procumbens L DONG WHA PHARM. CO., LTD. (KR) 2020-12-22 US claimed
EP-3485920-B1 COATING METHOD FOR A FOLDED BALLOON BRAUN MELSUNGEN AG (DE) 2020-05-20 EP claimed
US-20190275211-A1 SHELLAC AND PACLITAXEL COATED CATHETER BALLOONS EUROCOR TECH GMBH (DE) 2019-09-12 US claimed
CN-106957309-B The preparation method of lignanoids monomer in a kind of justicia 山东省分析测试中心 2019-07-30 CN claimed
EP-3485920-A1 COATING METHOD FOR A FOLDED BALLOON B. Braun Melsungen AG (DE) 2019-05-22 EP claimed
CN-109731206-A A kind of sacculus for biological body vessel bifurcated lesions and application thereof and operation method 中国医学科学院阜外医院 2019-05-10 CN claimed
US-20190134126-A1 PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING RESPIRATORY DISEASE COMPRISING EXTRACT OF JUSTICIA PROCUMBENS L. DONG WHA PHARM. CO., LTD. (KR) 2019-05-09 US claimed
US-20050176678-A1 Oligosaccharide or polysaccharide which contain sugar segments; antiproliferative agents; antiinflammatory agents; anticoagulants HEMOTEQ AG (DE) 2005-08-11 US claimed
US-20050129731-A1 Biocompatible, biostable coating of medical surfaces HEMOTEQ AG (DE) 2005-06-16 US claimed
WO-2005032611-A2 BIOCOMPATIBLE, BIOSTABLE COATING OF MEDICAL SURFACES HEMOTEQ GMBH (DE) 2005-04-14 WO claimed
US-20050060028-A1 Blood biocompatible layer and adjacent layer containing antiproliferative, antiinflammatory and/or antithrombotic active agent covalently and/or adhesively bound HEMOTEQ AG (DE) 2005-03-17 US claimed
EP-1501565-A1 COMPOUNDS AND METHOD FOR COATING SURFACES IN A HAEMOCOMPATIBLE MANNER Hemoteq GmbH (DE) 2005-02-02 EP claimed
CN-1568166-A Coated stent for preventing restenosis HEMOTEQ GMBH (DE) 2005-01-19 CN claimed
EP-1435877-A1 COATING OF STENTS FOR PREVENTING RESTENOSIS Hemoteq GmbH (DE) 2004-07-14 EP claimed
WO-2003094990-A1 COMPOUNDS AND METHOD FOR COATING SURFACES IN A HAEMOCOMPATIBLE MANNER HEMOTEQ GMBH (DE) 2003-11-20 WO claimed
EP-1336602-A1 Nitrate prodrugs able to release nitric oxide in a controlled and selective way and their use for prevention and treatment of inflammatory, ischemic and proliferative diseases Scaramuzzino, Giovanni (IT) 2003-08-20 EP claimed
WO-2003034944-A1 COATING OF STENTS FOR PREVENTING RESTENOSIS HEMOTEQ GMBH (DE) 2003-05-01 WO claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050176678-A1 Oligosaccharide or polysaccharide which contain sugar segments; antiproliferative agents; antiinflammatory agents; anticoagulants FUT5, CSGALNACT1, FUT6 ALDH1A1 2008/4885MAPT 4877/4885KDM4E 3618/4885
US-20050129731-A1 Biocompatible, biostable coating of medical surfaces MSR1, CD44, PIGS ALDH1A1 2298/4885MAPT 4641/4885KDM4E 4418/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.