SCHEMBL1683977

SCHEMBL1683977

COc1cccc(-c2ccc(C)cc2)c1C=CC#Cc1ccc(C(=O)O)cc1

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ RARB P10826 9/20 0.51
▸ RARA P10276 8/20 0.51
▸ RARG P13631 8/20 0.51
▸ RXRA P19793 1/20 0.41
▸ ABCG2 Q9UNQ0 1/20 0.39
▸ LTB4R Q15722 2/20 0.38
▸ TDP1 Q9NUW8 2/20 0.37
▸ L3MBTL1 Q9Y468 2/20 0.37
▸ LMNA P02545 1/20 0.37
▸ MAPK1 P28482 1/20 0.37
▸ ALDH1A1 P00352 2/20 0.37
▸ CPT1A P50416 1/20 0.37
▸ CPT1B Q92523 1/20 0.37
▸ SLC16A3 O15427 1/20 0.37
▸ KDM4E B2RXH2 1/20 0.37
▸ MEN1 O00255 1/20 0.37
▸ POLB P06746 1/20 0.37
▸ GAA P10253 1/20 0.37
▸ MAPT P10636 1/20 0.37
▸ RECQL P46063 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1683976 1.00 RARB (0.51) RARBRARARARGRXRAABCG2
SCHEMBL8168025 0.91 TDP1 (0.42) RARBRARARARGABCG2TDP1
SCHEMBL7930726 0.89 RARB (0.47) RARBRARARARGRXRATDP1
SCHEMBL7922680 0.86 RARB (0.51) RARBRARARARGRXRAALDH1A1
SCHEMBL7929287 0.85 RARB (0.50) RARBRARARARGRXRAALDH1A1
SCHEMBL1683959 0.83 RARB (0.48) RARBRARARARGRXRALTB4R
SCHEMBL1683960 0.83 RARB (0.48) RARBRARARARGRXRALTB4R
SCHEMBL8169474 0.80 EGFR (0.43) RARBRARARARGTDP1L3MBTL1
SCHEMBL1683992 0.80 RARB (0.53) RARBRARARARGRXRATDP1
SCHEMBL1683993 0.80 RARB (0.53) RARBRARARARGRXRATDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2020068665-A1 USE OF COLLAGEN BINDING DOMAINS TO DELIVER PRODUCTS TO SKIN FABIUS BIOTECHNOLOGY (US) 2020-04-02 — — WO claimed
EP-1255543-B1 USE OF RETINOID-TYPE COMPOUNDS AS ANTIBACTERIAL AGENTS AGAINST STAPHYLOCOCCUS AUREUS GALDERMA RES & DEV (FR) 2010-09-01 — — EP claimed
US-6858647-B2 Retinoid compounds suited for antibacterial applications GALDERMA RESEARCH & DEVELOPMENT S.N.C. (FR) 2005-02-22 — — US claimed
US-20030055110-A1 Retinoid compounds suited for antibacterial applications GALDERMA RESEARCH & DEVELOPMENT (FR) 2003-03-20 — — US claimed
US-20260035353-A1 PHENOL DERIVATIVES FOR USE AS ANTIMICROBIAL, ANTIBACTERIAL, BACTERICIDE SPECIAL PRODUCTS LINE S P A (IT) 2026-02-05 — — US disclosed
US-20220281835-A1 PHENOL DERIVATIVES FOR USE AS ANTIMICROBIAL, ANTIBACTERIAL, BACTERICIDE SPECIAL PRODUCTS LINE S P A (IT) 2022-09-08 — — US disclosed
US-20210338558-A1 USE OF COLLAGEN BINDING DOMAINS TO DELIVER PRODUCTS TO SKIN FABIUS BIOTECHNOLOGY (US) 2021-11-04 — — US disclosed
WO-2020068665-A1 USE OF COLLAGEN BINDING DOMAINS TO DELIVER PRODUCTS TO SKIN FABIUS BIOTECHNOLOGY (US) 2020-04-02 — — WO disclosed
EP-1711210-B1 COMBINED USE OF PRAME INHIBITORS AND HDAC INHIBITORS TOPOTARGET UK LTD (GB) 2013-12-11 — — EP disclosed
EP-2392677-A2 Combined use of prame inhibitors and hdac inhibitors TopoTarget UK Limited (GB) 2011-12-07 — — EP disclosed
US-7928081-B2 biodrugs contains siRNA or vector encoding siRNA, including a retinoid as antitumor agents, anticarcinogenic agents Bernards, Rene (NL) 2011-04-19 — — US disclosed
US-20080119424-A1 Combined Use of Prame Inhibitors and Hdac Inhibitors BERNARDS RENE 2008-05-22 — — US disclosed
US-6858647-B2 Retinoid compounds suited for antibacterial applications GALDERMA RESEARCH & DEVELOPMENT S.N.C. (FR) 2005-02-22 — — US disclosed
US-20030055110-A1 Retinoid compounds suited for antibacterial applications GALDERMA RESEARCH & DEVELOPMENT (FR) 2003-03-20 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260035353-A1 PHENOL DERIVATIVES FOR USE AS ANTIMICROBIAL, ANTIBACTERIAL, BACTERICIDE TLR7, GANC, ARG1 RARB 2413/4885RARA 2620/4885RARG 2152/4885
US-20210338558-A1 USE OF COLLAGEN BINDING DOMAINS TO DELIVER PRODUCTS TO SKIN COL14A1, COL2A1, COL1A1 RARB 987/4885RARA 1211/4885RARG 744/4885
US-20220281835-A1 PHENOL DERIVATIVES FOR USE AS ANTIMICROBIAL, ANTIBACTERIAL, BACTERICIDE UROD, PPARD, PGLS RARB 1666/4885RARA 1672/4885RARG 2311/4885
US-20080119424-A1 Combined Use of Prame Inhibitors and Hdac Inhibitors HDAC5, HDAC8, HDAC11 RARB 14/4885RARA 29/4885RARG 24/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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