SCHEMBL16841663

SCHEMBL16841663

CC(C)OCc1ccc(C#N)cc1F

nearest known ligand 0.44

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
FFAR1 O14842 1/20 0.40
FFAR4 Q5NUL3 1/20 0.40
FNTA P49354 5/20 0.39
FNTB P49356 5/20 0.39
NR3C1 P04150 1/20 0.38
PGR P06401 1/20 0.38
NR3C2 P08235 1/20 0.38
CETP P11597 1/20 0.37
PGGT1B P53609 3/20 0.36
MAPK14 Q16539 1/20 0.36
CTSB P07858 1/20 0.36
RORC P51449 1/20 0.35
GAA P10253 1/20 0.35
SMN1; SMN2 Q16637 1/20 0.35
PRMT5 O14744 1/20 0.35
EGFR P00533 1/20 0.35
CYP19A1 P11511 1/20 0.35
IDO1 P14902 1/20 0.35
AGXT P21549 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19387996 0.87 FNTA (0.39) FNTAFNTBCETPPGGT1BRORC
SCHEMBL25404947 0.85 RORC (0.38) FFAR1FFAR4FNTAFNTBNR3C1
SCHEMBL15423539 0.84 IDO1 (0.35) FFAR1FFAR4IDO1AGXT
SCHEMBL25717744 0.82 FFAR1 (0.37) FFAR1FFAR4FNTAFNTBNR3C1
SCHEMBL3641589 0.81 NR3C1 (0.43) FFAR1FFAR4NR3C1PGRNR3C2
SCHEMBL29506809 0.81 NR3C1 (0.43) FFAR1FFAR4NR3C1PGRNR3C2
SCHEMBL1715728 0.78 IDO1 (0.59) FFAR1FFAR4NR3C1PGRNR3C2
SCHEMBL21086643 0.78 FFAR1 (0.39) FFAR1FFAR4NR3C1PGRNR3C2
SCHEMBL12884378 0.78 FFAR1 (0.42) FFAR1FFAR4NR3C1PGRNR3C2
SCHEMBL11995181 0.78 S1PR1 (0.40) CETPSMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230150998-A1 COMPOUNDS AS GLP-1R AGONISTS Terns, Inc. 2023-05-18 US disclosed
US-20230150998-A1 COMPOUNDS AS GLP-1R AGONISTS Terns, Inc. 2023-05-18 US disclosed
US-10335409-B2 Inhibitors of hepatitis C virus GILEAD PHARMASSET LLC (US) 2019-07-02 US disclosed
US-9655944-B2 Inhibitors of hepatitis C virus GILEAD SCIENCES, INC. (US) 2017-05-23 US disclosed
US-20150175655-A1 INHIBITORS OF HEPATITIS C VIRUS GILEAD PHARMASSET LLC 2015-06-25 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150175655-A1 INHIBITORS OF HEPATITIS C VIRUS HAVCR2, SLC10A1, GOT1 FFAR1 2895/4885FFAR4 3819/4885FNTA 589/4885
US-20230150998-A1 COMPOUNDS AS GLP-1R AGONISTS GLP1R, GIPR, GCGR FFAR1 40/4885FFAR4 64/4885FNTA 2748/4885
US-10335409-B2 Inhibitors of hepatitis C virus HAVCR2, SLC10A1, GOT1 FFAR1 2573/4885FFAR4 3625/4885FNTA 594/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.