Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | BCL3 | P20749 | 1/20 | 0.39 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.38 |
| ▸ | QSOX1 | O00391 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL46961 | 0.84 | NTRK1 (0.40) | DRD4SMN1; SMN2MAPTRAB9AHTT | |
| SCHEMBL15433035 | 0.84 | DGAT1 (0.45) | DRD4SMN1; SMN2MAPTRAB9AHTT | |
| SCHEMBL15432993 | 0.83 | WNT3A (0.49) | ALDH1A1KDM4EKMT2AMEN1 | |
| SCHEMBL19595482 | 0.83 | RAF1 (0.42) | DRD4SMN1; SMN2MAPTRAB9AHTT | |
| SCHEMBL15433053 | 0.83 | FGFR1 (0.39) | DRD4SMN1; SMN2MAPTRAB9AHTT | |
| SCHEMBL46563 | 0.82 | TRPV4 (0.41) | KDM4EGAALMNA | |
| SCHEMBL46674 | 0.82 | KDM5A (0.43) | DRD4SMN1; SMN2MAPTRAB9AHTT | |
| SCHEMBL15433052 | 0.81 | MAPK14 (0.38) | DRD4MAPTNTRK1ALDH1A1HRH3 | |
| SCHEMBL46894 | 0.81 | LCK (0.51) | — | |
| SCHEMBL46570 | 0.81 | TRPV4 (0.39) | DRD4SMN1; SMN2MAPTKDM4EPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2590655-B1 | COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT | ARDELYX INC (US) | 2015-06-24 | — | — | EP | disclosed |