Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR2 | P50052 | 1/20 | 0.47 |
| ▸ | PTGER1 | P34995 | 2/20 | 0.43 |
| ▸ | PTGER4 | P35408 | 2/20 | 0.43 |
| ▸ | PTGER3 | P43115 | 2/20 | 0.43 |
| ▸ | PTGER2 | P43116 | 2/20 | 0.43 |
| ▸ | MAOA | P21397 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 1/20 | 0.42 |
| ▸ | HTR1A | P08908 | 1/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.42 |
| ▸ | DRD1 | P21728 | 1/20 | 0.42 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.42 |
| ▸ | DRD4 | P21917 | 1/20 | 0.42 |
| ▸ | DRD5 | P21918 | 1/20 | 0.42 |
| ▸ | DRD3 | P35462 | 1/20 | 0.42 |
| ▸ | PTGFR | P43088 | 1/20 | 0.42 |
| ▸ | PTGIR | P43119 | 1/20 | 0.42 |
| ▸ | RXRB | P28702 | 3/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16844583 | 1.00 | AGTR2 (0.47) | AGTR2PTGER1PTGER4PTGER3PTGER2 | |
| SCHEMBL16844599 | 1.00 | AGTR2 (0.47) | AGTR2PTGER1PTGER4PTGER3PTGER2 | |
| SCHEMBL16844600 | 0.86 | L3MBTL1 (0.45) | AGTR2PTGER1MAOAMAOBMAPT | |
| SCHEMBL16844588 | 0.86 | L3MBTL1 (0.45) | AGTR2PTGER1MAOAMAOBMAPT | |
| SCHEMBL3029194 | 0.81 | AGTR2 (0.50) | AGTR2PTGER1PTGER4PTGER3PTGER2 | |
| SCHEMBL16844570 | 0.81 | MAPT (0.45) | AGTR2PTGER1PTGER4PTGER3PTGER2 | |
| SCHEMBL9791959 | 0.76 | AGTR2 (0.46) | AGTR2MAOAMAOBHTR1ASLC6A2 | |
| SCHEMBL20573458 | 0.74 | HTR1A (0.47) | AGTR2MAOAMAOBHTR1ASLC6A2 | |
| SCHEMBL1844734 | 0.74 | MAOA (0.55) | AGTR2MAOAMAOBHTR1ASLC6A2 | |
| SCHEMBL16445036 | 0.73 | FFAR1 (0.51) | MAOAMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015095261-A1 | NOVEL TRICYCLIC CALCIUM SENSING RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME CORP. (US) | 2015-06-25 | — | — | WO | disclosed |
| WO-2015089842-A1 | NOVEL TRICYCLIC CALCIUM SENSING RECEPTOR ANTAGONISTS FOR THE TREATMENT OF OSTEOPOROSIS | MERCK SHARP & DOHME CORP. (US) | 2015-06-25 | — | — | WO | disclosed |