Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | ELANE | P08246 | 1/20 | 0.42 |
| ▸ | BCL6 | P41182 | 1/20 | 0.39 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.37 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.36 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.36 |
| ▸ | CDK9 | P50750 | 1/20 | 0.36 |
| ▸ | IKBKB | O14920 | 1/20 | 0.36 |
| ▸ | CHUK | O15111 | 1/20 | 0.36 |
| ▸ | RORC | P51449 | 1/20 | 0.35 |
| ▸ | GRM5 | P41594 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15805469 | 0.87 | L3MBTL1 (0.42) | MAPTLMNAHTTL3MBTL1SCN9A | |
| SCHEMBL13306502 | 0.83 | ELANE (0.57) | MAPTMEN1LMNAHTTKMT2A | |
| SCHEMBL15805329 | 0.83 | ALDH1A1 (0.44) | MEN1KMT2AL3MBTL1HSD17B10TDP1 | |
| SCHEMBL18356400 | 0.82 | LRRK2 (0.43) | MAPTMEN1LMNAHTTKMT2A | |
| SCHEMBL15805410 | 0.82 | PKM (0.46) | MEN1LMNAHTTKMT2AL3MBTL1 | |
| SCHEMBL20744459 | 0.81 | L3MBTL1 (0.45) | MAPTLMNAELANEL3MBTL1HSD11B1 | |
| SCHEMBL30674345 | 0.81 | L3MBTL1 (0.45) | MAPTLMNAELANEL3MBTL1HSD11B1 | |
| SCHEMBL15805335 | 0.80 | SCN9A (0.40) | MAPTMEN1KMT2ADYRK1AL3MBTL1 | |
| SCHEMBL16023207 | 0.80 | KDM4E (0.46) | MAPTMEN1LMNAKMT2AL3MBTL1 | |
| SCHEMBL15805388 | 0.80 | L3MBTL1 (0.38) | MEN1HTTKMT2AL3MBTL1HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3083618-B1 | NOVEL 3,4-DISUBSTITUTED-1H-PYRROLO[2,3-B]PYRIDINES AND 4,5-DISUBSTITUTED-7H-PYRROLO[2,3-C]PYRIDAZINES AS LRRK2 INHIBITORS | PFIZER (US) | 2018-02-21 | — | — | EP | disclosed |
| US-9695171-B2 | 3,4-disubstituted-1 H-pyrrolo[2,3-b]pyridines and 4,5-disubstituted-7H-pyrrolo[2,3-c]pyridazines as LRRK2 inhibitors | PFIZER INC. (US) | 2017-07-04 | — | — | US | disclosed |
| US-9695171-B2 | 3,4-disubstituted-1 H-pyrrolo[2,3-b]pyridines and 4,5-disubstituted-7H-pyrrolo[2,3-c]pyridazines as LRRK2 inhibitors | PFIZER INC. (US) | 2017-07-04 | — | — | US | disclosed |
| US-20170002000-A1 | NOVEL 3,4-DISUBSTITUTED-1H-PYRROLO[2,3-b]PYRIDINES AND 4,5-DISUBSTITUTED-7H-PYRROLO[2,3-c]PYRIDAZINES AS LRRK2 INHIBITORS | PFIZER INC. (US) | 2017-01-05 | — | — | US | disclosed |
| US-20170002000-A1 | NOVEL 3,4-DISUBSTITUTED-1H-PYRROLO[2,3-b]PYRIDINES AND 4,5-DISUBSTITUTED-7H-PYRROLO[2,3-c]PYRIDAZINES AS LRRK2 INHIBITORS | PFIZER INC. (US) | 2017-01-05 | — | — | US | disclosed |
| WO-2015092592-A1 | NOVEL 3,4-DISUBSTITUTED-1H-PYRROLO[2,3-B]PYRIDINES AND 4,5-DISUBSTITUTED-7H-PYRROLO[2,3-C]PYRIDAZINES AS LRRK2 INHIBITORS | PFIZER INC. (US) | 2015-06-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170002000-A1 | NOVEL 3,4-DISUBSTITUTED-1H-PYRROLO[2,3-b]PYRIDINES AND 4,5-DISUBSTITUTED-7H-PYRROLO[2,3-c]PYRIDAZINES AS LRRK2 INHIBITORS | LRRK2, PARK7, BRCA1 | MAPT 73/4885MEN1 2491/4885LMNA 2627/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.