Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FEN1 | P39748 | 13/20 | 0.34 |
| ▸ | ALOX5AP | P20292 | 8/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.32 |
| ▸ | ADK | P55263 | 1/20 | 0.31 |
| ▸ | TDO2 | P48775 | 1/20 | 0.31 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.30 |
| ▸ | ABL1 | P00519 | 1/20 | 0.30 |
| ▸ | EGFR | P00533 | 1/20 | 0.30 |
| ▸ | HCK | P08631 | 1/20 | 0.30 |
| ▸ | SRC | P12931 | 1/20 | 0.30 |
| ▸ | KDR | P35968 | 1/20 | 0.30 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.30 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.30 |
| ▸ | MTOR | P42345 | 1/20 | 0.30 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.30 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.30 |
| ▸ | PRKDC | P78527 | 1/20 | 0.30 |
| ▸ | JAK2 | O60674 | 2/20 | 0.30 |
| ▸ | JAK1 | P23458 | 2/20 | 0.30 |
| ▸ | TYK2 | P29597 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16857688 | 0.76 | GAA (0.45) | PIK3CDABL1EGFRHCKSRC | |
| SCHEMBL29897242 | 0.64 | RET (0.56) | HCKKDR | |
| SCHEMBL3768868 | 0.62 | LRRK2 (0.64) | — | |
| SCHEMBL23917192 | 0.62 | MAP4K4 (0.38) | PIK3CDABL1EGFRHCKSRC | |
| SCHEMBL4929263 | 0.61 | TDO2 (0.47) | FEN1ALOX5APADKTDO2 | |
| SCHEMBL31648987 | 0.60 | PSMB5 (0.40) | FEN1MAPK1TDO2 | |
| SCHEMBL16655157 | 0.60 | PIK3CD (0.47) | PIK3CDABL1EGFRHCKSRC | |
| SCHEMBL2789204 | 0.60 | TDO2 (0.46) | FEN1ALOX5APADKTDO2JAK2 | |
| SCHEMBL18855054 | 0.59 | HSP90AA1 (0.36) | — | |
| SCHEMBL30867934 | 0.59 | PDGFRB (0.41) | FEN1ALOX5APMAPK1TDO2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2408772-B1 | COMPOUNDS | MEDICAL RES COUNCIL TECHNOLOGY (GB) | 2015-07-01 | — | — | EP | disclosed |