Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GFER | P55789 | 1/20 | 0.43 |
| ▸ | MET | P08581 | 1/20 | 0.43 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | RBP4 | P02753 | 1/20 | 0.41 |
| ▸ | SLC6A9 | P48067 | 2/20 | 0.41 |
| ▸ | NCF1 | P14598 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | DRD3 | P35462 | 1/20 | 0.40 |
| ▸ | TACR1 | P25103 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | CCR1 | P32246 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | CYP46A1 | Q9Y6A2 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1686153 | 0.88 | CKS1B (0.52) | LMNATSHRNPSR1MAPTALDH1A1 | |
| SCHEMBL28792495 | 0.87 | MET (0.41) | METCXCR3KCNH2RBP4SLC6A9 | |
| SCHEMBL1686115 | 0.82 | HTR7 (0.50) | NCF1 | |
| SCHEMBL1686089 | 0.81 | SLC6A9 (0.38) | METCXCR3KCNH2SLC6A9DRD2 | |
| SCHEMBL1686099 | 0.77 | CKS1B (0.52) | — | |
| SCHEMBL27838527 | 0.76 | MET (0.47) | METSLC6A9LMNANPSR1HTT | |
| SCHEMBL1686109 | 0.76 | CKS1B (0.50) | — | |
| SCHEMBL1686128 | 0.74 | CKS1B (0.48) | ALDH1A1 | |
| SCHEMBL1686116 | 0.73 | CKS1B (0.47) | — | |
| SCHEMBL5238054 | 0.71 | HTR1A (0.57) | CXCR3KCNH2RBP4DRD2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102171189-B | Piperazin-1-yl-trifluoromethyl-substituted-pyridines as fast dissociating dopamine 2 receptor antagonists | JANSSEN PHARMACEUTICA NV | 2013-11-20 | — | — | CN | disclosed |
| CN-102171189-A | Piperazin-1-yl-trifluoromethyl-substituted-pyridines as fast dissociating dopamine 2 receptor antagonists | JANSSEN PHARMACEUTICA NV | 2011-08-31 | — | — | CN | disclosed |
| EP-2307374-A1 | PIPERAZIN-1-YL-TRIFLUOROMETHYL-SUBSTITUTED-PYRIDINES AS FAST DISSOCIATING DOPAMINE 2 RECEPTOR ANTAGONISTS | Janssen Pharmaceutica, N.V. (BE) | 2011-04-13 | — | — | EP | disclosed |
| WO-2010012758-A1 | PIPERAZIN-1-YL-TRIFLUOROMETHYL-SUBSTITUTED-PYRIDINES AS FAST DISSOCIATING DOPAMINE 2 RECEPTOR ANTAGONISTS | JANSSEN PHARMACEUTICA NV (BE) | 2010-02-04 | — | — | WO | disclosed |