SCHEMBL16864844

SCHEMBL16864844

C=C(C)C(=O)OCC(CC)N1C(=O)c2ccc3c4c(ccc(c24)C1=O)C(=O)N(N1CCCc2ccccc21)C3=O

nearest known ligand 0.39

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
MAPT P10636 4/20 0.39
GAA P10253 3/20 0.35
SMN1; SMN2 Q16637 3/20 0.35
NOTUM Q6P988 1/20 0.35
KMT2A Q03164 4/20 0.34
PRMT5 O14744 1/20 0.34
WDR77 Q9BQA1 1/20 0.34
ATM Q13315 1/20 0.34
ALDH1A1 P00352 4/20 0.33
NPSR1 Q6W5P4 3/20 0.33
MAPK1 P28482 2/20 0.33
POLB P06746 2/20 0.33
TSHR P16473 2/20 0.32
MEN1 O00255 2/20 0.32
GRM7 Q14831 1/20 0.32
HTT P42858 1/20 0.32
RECQL P46063 1/20 0.32
HPGD P15428 1/20 0.32
LMNA P02545 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10100516 0.75 SMN1; SMN2 (0.45) MAPTSMN1; SMN2NOTUMKMT2AALDH1A1
SCHEMBL24756852 0.70 KDM4E (0.49) MAPTGAAKMT2AALDH1A1NPSR1
SCHEMBL16864797 0.67 CHRM2 (0.43) MAPTSMN1; SMN2NOTUMKMT2AALDH1A1
SCHEMBL6663892 0.65 KMT2A (0.44) GAAKMT2AALDH1A1NPSR1MAPK1
SCHEMBL16838565 0.65 TSHR (0.41) TSHRHPGD
SCHEMBL10018474 0.63 PIN1 (0.36) SMN1; SMN2ALDH1A1HPGD
SCHEMBL16864806 0.62 USP2 (0.48) MAPTGAASMN1; SMN2KMT2AALDH1A1
SCHEMBL12382277 0.62 TERT (0.38) GAASMN1; SMN2KMT2AATMALDH1A1
SCHEMBL9915820 0.62 TERT (0.38) GAASMN1; SMN2KMT2AATMALDH1A1
SCHEMBL21925319 0.62 TSHR (0.49) MAPTALDH1A1NPSR1MAPK1TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9335645-B2 Electrophotographic photosensitive member, process cartridge and electrophotographic apparatus CANON KABUSHIKI KAISHA (JP) 2016-05-10 US disclosed
US-9335645-B2 Electrophotographic photosensitive member, process cartridge and electrophotographic apparatus CANON KABUSHIKI KAISHA (JP) 2016-05-10 US disclosed
US-20150185633-A1 ELECTROPHOTOGRAPHIC PHOTOSENSITIVE MEMBER, PROCESS CARTRIDGE AND ELECTROPHOTOGRAPHIC APPARATUS CANON KABUSHIKI KAISHA (JP) 2015-07-02 US disclosed
US-20150185633-A1 ELECTROPHOTOGRAPHIC PHOTOSENSITIVE MEMBER, PROCESS CARTRIDGE AND ELECTROPHOTOGRAPHIC APPARATUS CANON KABUSHIKI KAISHA (JP) 2015-07-02 US disclosed