SCHEMBL16865391

SCHEMBL16865391

O=C1NC(=O)C(Br)(c2ccccc2)C(=O)N1c1ccccc1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GAA P10253 1/20 0.41
CNR1 P21554 1/20 0.40
ELANE P08246 3/20 0.40
GRK5 P34947 1/20 0.39
TYRO3 Q06418 1/20 0.39
DYRK1B Q9Y463 1/20 0.39
MGLL Q99685 1/20 0.38
ALDH1A1 P00352 3/20 0.38
MEN1 O00255 3/20 0.38
KMT2A Q03164 3/20 0.38
LMNA P02545 3/20 0.38
KDM4E B2RXH2 3/20 0.38
MAPT P10636 2/20 0.38
HSD17B10 Q99714 2/20 0.38
CASP1 P29466 1/20 0.38
ITGA4 P13612 1/20 0.37
ITGB7 P26010 1/20 0.37
USP2 O75604 1/20 0.36
NR4A1 P22736 1/20 0.36
PGR P06401 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16865387 0.76 LMNA (0.41) GAACNR1ELANEGRK5TYRO3
SCHEMBL16865445 0.72 ELANE (0.41) GAAELANEGRK5TYRO3DYRK1B
SCHEMBL4038795 0.71 MMP9 (0.57) ALDH1A1KMT2ALMNAMAPT
SCHEMBL16865421 0.70 ELANE (0.42) GAAELANEALDH1A1KMT2ALMNA
Phetharbital SCHEMBL78655 0.69 ELANE (0.71) ELANEGRK5TYRO3DYRK1BLMNA
SCHEMBL16865429 0.67 MAPT (0.48) GAAMGLLALDH1A1MEN1KMT2A
SCHEMBL11465842 0.67 AR (0.68) ELANEMEN1KMT2ALMNAPGR
SCHEMBL828772 0.67 ELANE (0.53) ELANEGRK5TYRO3DYRK1BALDH1A1
SCHEMBL7481702 0.66 MMP2 (0.64) GAAELANEMEN1KMT2ALMNA
SCHEMBL16865399 0.66 ELANE (0.55) ELANEALDH1A1LMNAKDM4EMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20150185368-A1 OPTICAL FILM, POLARIZING PLATE AND LIQUID CRYSTAL DISPLAY USING THE SAME, AND COMPOUND FUJIFILM CORPORATION (JP) 2015-07-02 US disclosed
US-20150185368-A1 OPTICAL FILM, POLARIZING PLATE AND LIQUID CRYSTAL DISPLAY USING THE SAME, AND COMPOUND FUJIFILM CORPORATION (JP) 2015-07-02 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150185368-A1 OPTICAL FILM, POLARIZING PLATE AND LIQUID CRYSTAL DISPLAY USING THE SAME, AND COMPOUND C1R, C1S, C3AR1 GAA 4562/4885CNR1 1040/4885ELANE 2715/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.