Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 4/20 | 0.38 |
| ▸ | NSD2 | O96028 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 11/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.34 |
| ▸ | HPGD | P15428 | 4/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.32 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16872294 | 0.83 | KDM4E (0.39) | MAPK1NSD2KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL16872249 | 0.81 | NOS3 (0.36) | ALDH1A1GAANPSR1TSHRCYP1A2 | |
| SCHEMBL16872037 | 0.80 | MAPK1 (0.38) | MAPK1NSD2KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL16872091 | 0.78 | NOS3 (0.39) | KDM4E | |
| SCHEMBL16872034 | 0.78 | ACHE (0.35) | MAPK1KDM4EALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL16872171 | 0.75 | ACHE (0.38) | MAPK1KDM4EHSD17B10HPGDUSP2 | |
| SCHEMBL16872138 | 0.75 | ACHE (0.36) | KDM4EHSD17B10TSHRHTTCYP3A4 | |
| SCHEMBL16872210 | 0.71 | GRM5 (0.37) | KDM4EALDH1A1ADORA2ACYP1A2CYP3A4 | |
| SCHEMBL16987349 | 0.71 | KDM4E (0.32) | KDM4EADORA2A | |
| SCHEMBL16872289 | 0.71 | ALOX5AP (0.37) | KDM4EALDH1A1SMN1; SMN2ADORA2AHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150225404-A1 | PYRIDINE DERIVATIVE AND MEDICINE | NIPPON SHINYAKU CO., LTD. (JP) | 2015-08-13 | — | — | US | disclosed |
| EP-2891656-A1 | PYRIDINE DERIVATIVE AND MEDICINE | Nippon Shinyaku Co., Ltd. (JP) | 2015-07-08 | — | — | EP | disclosed |
| CN-104755471-A | Pyridine derivative and drug | NIPPON SHINYAKU CO LTD | 2015-07-01 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150225404-A1 | PYRIDINE DERIVATIVE AND MEDICINE | TRPV1, TRPV5, TRPM5 | MAPK1 329/4885NSD2 3669/4885KDM4E 1569/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.