SCHEMBL1687807

SCHEMBL1687807

c1cc(-c2cccc(-c3cccc(-n4c5ccccc5c5cc(-n6c7ccccc7c7ccccc76)ccc54)c3)c2)cc(-c2cccc(-c3cccc4c3oc3ccccc34)c2)c1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALOX5 P09917 2/20 0.48
GGPS1 O95749 1/20 0.42
PRKDC P78527 9/20 0.39
PTGES2 Q9H7Z7 1/20 0.39
PRMT5 O14744 1/20 0.39
WDR77 Q9BQA1 1/20 0.39
ATM Q13315 2/20 0.36
KDM4E B2RXH2 2/20 0.36
L3MBTL1 Q9Y468 1/20 0.36
RXFP1 Q9HBX9 2/20 0.33
PIK3CD O00329 1/20 0.33
PIK3CB P42338 1/20 0.33
ALDH1A1 P00352 1/20 0.33
LMNA P02545 1/20 0.33
PPARG P37231 1/20 0.33
NR2E3 Q9Y5X4 1/20 0.33
NCOR2 Q9Y618 1/20 0.33
PLA2G2A P14555 1/20 0.33
PLA2G4A P47712 1/20 0.33
HDAC8 Q9BY41 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1687753 1.00 ALOX5 (0.48) ALOX5GGPS1PRKDCPTGES2PRMT5
SCHEMBL1687786 1.00 ALOX5 (0.48) ALOX5GGPS1PRKDCPTGES2PRMT5
SCHEMBL14867958 0.98 ALOX5 (0.50) ALOX5GGPS1PRKDCPTGES2PRMT5
SCHEMBL1687793 0.98 ALOX5 (0.50) ALOX5GGPS1PRKDCPTGES2PRMT5
SCHEMBL12996612 0.95 ALOX5 (0.52) ALOX5GGPS1PRKDCPTGES2PRMT5
SCHEMBL21578704 0.94 ALOX5 (0.48) ALOX5GGPS1PRKDCPTGES2PRMT5
SCHEMBL1687773 0.94 ALOX5 (0.43) ALOX5GGPS1PRKDCPTGES2PRMT5
SCHEMBL1687698 0.94 ALOX5 (0.47) ALOX5GGPS1PRKDCPTGES2PRMT5
SCHEMBL1687741 0.94 ALOX5 (0.50) ALOX5GGPS1PRKDCPTGES2PRMT5
SCHEMBL13830074 0.94 ALOX5 (0.52) ALOX5GGPS1PRKDCPTGES2PRMT5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9401482-B2 Organic electroluminescent materials and devices UNIVERSAL DISPLAY CORPORATION (US) 2016-07-26 US disclosed
US-9401482-B2 Organic electroluminescent materials and devices UNIVERSAL DISPLAY CORPORATION (US) 2016-07-26 US disclosed
US-20150097176-A1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES UNIVERSAL DISPLAY CORPORATION (US) 2015-04-09 US disclosed
US-20150097176-A1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES UNIVERSAL DISPLAY CORPORATION (US) 2015-04-09 US disclosed
US-8932734-B2 Organic electroluminescent materials and devices UNIVERSAL DISPLAY CORPORATION (US) 2015-01-13 US disclosed
US-8932734-B2 Organic electroluminescent materials and devices UNIVERSAL DISPLAY CORPORATION (US) 2015-01-13 US disclosed
US-20120086329-A1 Novel 3, 9-Linked Oliogocarbazole-Based Hosts, Containing DBT and DBF Fragments, Separated by Aromatic Spacers Universal Disolay Corporation (US) 2012-04-12 US disclosed
US-20120086329-A1 Novel 3, 9-Linked Oliogocarbazole-Based Hosts, Containing DBT and DBF Fragments, Separated by Aromatic Spacers Universal Disolay Corporation (US) 2012-04-12 US disclosed
WO-2012048266-A1 NOVEL 3, 9-LINKED OLIGOCARBAZOLE-BASED HOSTS, CONTAINING DBT AND DBR FRAGMENTS, SEPARATED BY AROMATIC SPACERS UNIVERSAL DISPLAY CORPORATION (US) 2012-04-12 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120086329-A1 Novel 3, 9-Linked Oliogocarbazole-Based Hosts, Containing DBT and DBF Fragments, Separated by Aromatic Spacers DBF4, OGFOD1, DDT ALOX5 1460/4885GGPS1 404/4885PRKDC 2338/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.