Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 15/20 | 0.65 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | PGR | P06401 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.34 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL849686 | 0.78 | AR (0.72) | ARRAB9AMEN1LMNAKMT2A | |
| SCHEMBL1191623 | 0.75 | AR (0.68) | ARRAB9AMEN1LMNATP53 | |
| SCHEMBL22288743 | 0.74 | AR (0.65) | ARRAB9AMEN1LMNATP53 | |
| SCHEMBL28872810 | 0.74 | HTR6 (0.42) | RAB9APKMHSD11B1 | |
| SCHEMBL28291525 | 0.74 | AR (0.42) | ARRAB9APKMMEN1KMT2A | |
| SCHEMBL28118256 | 0.73 | AR (0.64) | ARRAB9AMEN1LMNATP53 | |
| SCHEMBL28118768 | 0.72 | AR (0.41) | ARMEN1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL5906374 | 0.70 | AR (0.60) | ARMEN1TSHRKMT2A | |
| SCHEMBL4025469 | 0.69 | LMNA (0.55) | ARMEN1LMNAKMT2ASMN1; SMN2 | |
| SCHEMBL25316229 | 0.69 | PIK3CD (0.43) | ARHSD11B1LMNACYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106573921-B | Imidazolidine-2, 4-dione derivatives | 博福-益普生（天津）制药有限公司 | 2019-05-07 | — | — | CN | disclosed |
| EP-3089975-B1 | NOVEL IMIDAZOLIDINE-2, 4-DIONE DERIVATIVES | IPSEN PHARMA SAS (FR) | 2018-06-06 | — | — | EP | disclosed |
| US-9676752-B2 | Imidazolidine-2,4-dione derivatives | IPSEN PHARMA S.A.S. (FR) | 2017-06-13 | — | — | US | disclosed |
| CN-106573921-A | Novel imidazolidine-2, 4-dione derivatives | 博福-益普生（天津）制药有限公司 | 2017-04-19 | — | — | CN | disclosed |
| EP-3089975-A1 | NOVEL IMIDAZOLIDINE-2, 4-DIONE DERIVATIVES | IPSEN PHARMA S.A.S. (FR) | 2016-11-09 | — | — | EP | disclosed |
| US-20160318902-A1 | NOVEL IMIDAZOLIDINE-2,4-DIONE DERIVATIVES | IPSEN PHARMA S.A.S. (FR) | 2016-11-03 | — | — | US | disclosed |
| WO-2015100613-A1 | NOVEL IMIDAZOLIDINE-2, 4-DIONE DERIVATIVES | BEAUFOUR IPSEN TIANJIN PHARMACEUTICAL CO., LTD (CN) | 2015-07-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160318902-A1 | NOVEL IMIDAZOLIDINE-2,4-DIONE DERIVATIVES | MKI67, CCNI, CDKN1A | AR 3381/4885RAB9A 1451/4885PKM 2782/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.