Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.46 |
| ▸ | TP53 | P04637 | 6/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | THRB | P10828 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | FAAH | O00519 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1759441 | 0.94 | MAPT (0.46) | MAPTTP53LMNATHRBPOLB | |
| SCHEMBL16880936 | 0.84 | AKT1 (0.35) | MAPTTP53LMNAFAAHHTR2C | |
| SCHEMBL16059449 | 0.82 | ALDH1A1 (0.34) | POLBFAAHKMT2A | |
| SCHEMBL14933657 | 0.81 | ESR1 (0.42) | MAPTFAAHMEN1HTTKMT2A | |
| SCHEMBL8265372 | 0.80 | SOS1 (0.39) | MAPTTP53FAAHHTTKMT2A | |
| SCHEMBL7239984 | 0.79 | LMNA (0.43) | MAPTLMNAPOLBMEN1HTT | |
| SCHEMBL1759492 | 0.77 | PDPK1 (0.35) | MAPTFAAHHTR2CKMT2A | |
| SCHEMBL12636119 | 0.77 | HIF1A (0.38) | MAPTTP53MEN1KMT2A | |
| SCHEMBL16880854 | 0.77 | KMT2A (0.40) | MAPTPOLBMEN1KMT2A | |
| SCHEMBL16062000 | 0.75 | ALDH1A1 (0.32) | KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3089746-A1 | THERAPEUTIC INHIBITORY COMPOUNDS | Lifesci Pharmaceuticals, Inc. (BB) | 2016-11-09 | — | — | EP | disclosed |
| WO-2015103317-A1 | THERAPEUTIC INHIBITORY COMPOUNDS | LIFESCI PHARMACEUTICALS, INC. (BB) | 2015-07-09 | — | — | WO | disclosed |