Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | CRHR1 | P34998 | 3/20 | 0.31 |
| ▸ | S100B | P04271 | 1/20 | 0.31 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12242775 | 0.77 | HTT (0.32) | ALDH1A1HTT | |
| SCHEMBL22057962 | 0.77 | HTT (0.32) | ALDH1A1HTTL3MBTL1 | |
| SCHEMBL16882349 | 0.75 | STK4 (0.35) | CRHR1 | |
| SCHEMBL12221454 | 0.74 | LMNA (0.32) | HTTSMN1; SMN2 | |
| SCHEMBL9761821 | 0.71 | ALDH1A1 (0.42) | ALDH1A1HTTSMN1; SMN2KDM4EMAPT | |
| SCHEMBL11307064 | 0.70 | AOC3 (0.32) | — | |
| SCHEMBL27516671 | 0.69 | LATS1 (0.42) | ALDH1A1HTTKDM4EMAPT | |
| SCHEMBL16882342 | 0.68 | CTH (0.34) | CRHR1 | |
| SCHEMBL2028609 | 0.65 | — | — | |
| SCHEMBL16882354 | 0.65 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9073907-B2 | Thiazoles derivatives and their use as positive allosteric modulators of metabotropic glutamate receptors | ADDEX PHARMA S.A. (CH) | 2015-07-07 | — | — | US | disclosed |