Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 1/20 | 0.45 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.45 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.45 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL838877 | 0.78 | GRM5 (0.55) | GRM5GRM1GRM2GRM4 | |
| SCHEMBL10160845 | 0.77 | TP53 (0.30) | — | |
| Hydrochloric Acid SCHEMBL10875068 | 0.74 | GRM5 (0.52) | GRM5GRM1GRM2GRM4 | |
| SCHEMBL20130279 | 0.73 | GRM5 (0.46) | GRM5GRM1GRM2GRM4 | |
| SCHEMBL16887658 | 0.70 | GRM5 (0.44) | GRM5GRM1GRM2GRM4 | |
| SCHEMBL10160060 | 0.70 | GRM5 (0.41) | GRM5GRM1GRM2GRM4 | |
| SCHEMBL15055615 | 0.65 | GRM5 (0.50) | GRM5GRM1GRM2GRM4 | |
| SCHEMBL10209770 | 0.65 | GRM5 (0.40) | GRM5GRM1GRM2GRM4 | |
| SCHEMBL4732666 | 0.64 | GRM5 (0.42) | GRM5GRM1GRM2GRM4 | |
| SCHEMBL10136463 | 0.62 | FFAR3 (0.38) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9458171-B2 | Pyrrolidinyl sulfone RORγ modulators | BRISTOL-MYERS SQUIBB COMPANY (US) | 2016-10-04 | — | — | US | disclosed |
| US-20150191483-A1 | PYRROLIDINYL SULFONE RORGAMMA MODULATORS | BRISTOL-MYERS SQUIBB COMPANY | 2015-07-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150191483-A1 | PYRROLIDINYL SULFONE RORGAMMA MODULATORS | RORC, RORB, RORA | GRM5 728/4885GRM1 427/4885GRM2 753/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.