Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 20/20 | 0.86 |
| ▸ | NR1I2 | O75469 | 3/20 | 0.69 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16886404 | 0.93 | RORC (1.00) | RORCNR1I2NR1H3 | |
| SCHEMBL16891685 | 0.88 | RORC (1.00) | RORCNR1I2 | |
| SCHEMBL19129007 | 0.87 | RORC (0.97) | RORCNR1I2 | |
| SCHEMBL16875431 | 0.82 | RORC (1.00) | RORCNR1I2NR1H3 | |
| SCHEMBL16875432 | 0.82 | RORC (1.00) | RORCNR1I2NR1H3 | |
| SCHEMBL16875508 | 0.82 | RORC (1.00) | RORCNR1I2NR1H3 | |
| Hydrochloric Acid SCHEMBL16875449 | 0.81 | RORC (0.98) | RORCNR1I2NR1H3 | |
| Hydrochloric Acid SCHEMBL16875317 | 0.81 | RORC (0.98) | RORCNR1I2NR1H3 | |
| Hydrochloric Acid SCHEMBL16875584 | 0.81 | RORC (0.98) | RORCNR1I2NR1H3 | |
| SCHEMBL16891743 | 0.77 | RORC (0.95) | RORCNR1I2NR1H3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9637455-B2 | Heterocyclic sulfone RORγ modulators | BRISTOL-MYERS SQUIBB COMPANY (US) | 2017-05-02 | — | — | US | disclosed |
| US-9637455-B2 | Heterocyclic sulfone RORγ modulators | BRISTOL-MYERS SQUIBB COMPANY (US) | 2017-05-02 | — | — | US | disclosed |
| US-20160326115-A1 | HETEROCYCLIC SULFONE ROR GAMMA MODULATORS | BRISTOL MYERS SQUIBB CO (US) | 2016-11-10 | — | — | US | disclosed |
| WO-2015103510-A1 | HETEROCYCLIC SULFONE AS ROR-GAMMA MODULATORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2015-07-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160326115-A1 | HETEROCYCLIC SULFONE ROR GAMMA MODULATORS | RORC, RORB, RORA | RORC 1/4885NR1I2 6/4885NR1H3 9/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.