Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | ALDH1A2 | O94788 | 3/20 | 0.39 |
| ▸ | ALDH1A3 | P47895 | 3/20 | 0.39 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | TDO2 | P48775 | 2/20 | 0.36 |
| ▸ | IDO2 | Q6ZQW0 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | APAF1 | O14727 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | MITF | O75030 | 1/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.36 |
| ▸ | IDO1 | P14902 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5611595 | 0.90 | GRM1 (0.41) | ALDH1A1ALDH1A2ALDH1A3GRM1MAPT | |
| SCHEMBL5611636 | 0.88 | PTGS2 (0.40) | ALDH1A1GRM1MAPTPTGS2KDM4E | |
| SCHEMBL1688979 | 0.88 | GRM1 (0.40) | ALDH1A1ALDH1A2ALDH1A3GRM1GLA | |
| SCHEMBL1688917 | 0.87 | ALDH1A1 (0.41) | ALDH1A1ALDH1A2ALDH1A3GRM1MAPT | |
| SCHEMBL5611869 | 0.85 | MAPT (0.49) | ALDH1A1GRM1MAPTPTGS2KDM4E | |
| SCHEMBL1688889 | 0.85 | MAPT (0.49) | ALDH1A1GRM1MAPTPTGS2KDM4E | |
| SCHEMBL1689250 | 0.85 | ALDH1A2 (0.44) | ALDH1A1ALDH1A2ALDH1A3GRM1MAPT | |
| SCHEMBL5611971 | 0.83 | GRM1 (0.41) | ALDH1A1ALDH1A2ALDH1A3GRM1MAPT | |
| SCHEMBL1688913 | 0.83 | MEN1 (0.51) | GRM1MAPTPTGS2KDM4EPKM | |
| SCHEMBL5611587 | 0.82 | MAPT (0.41) | ALDH1A1GRM1MAPTPTGS2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1807429-A2 | COMPOUNDS AND COMPOSITIONS AS INHIBITORS OF CANNABINOID RECEPTOR 1 ACTIVITY | IRM, LLC (BM) | 2007-07-18 | — | — | EP | claimed |
| WO-2006047516-A2 | COMPOUNDS AND COMPOSITIONS AS INHIBITORS OF CANNABINOID RECEPTOR 1 ACTIVITY | IRM LLC (BM) | 2006-05-04 | — | — | WO | claimed |