Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 5/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | GRM5 | P41594 | 1/20 | 0.39 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1688982 | 0.94 | KDM4E (0.43) | PTGS2GRM1KDM4EMAPK1ADORA3 | |
| SCHEMBL1688973 | 0.92 | KDM4E (0.46) | PTGS2MAPTGRM5GRM1KDM4E | |
| SCHEMBL5611636 | 0.90 | PTGS2 (0.40) | PTGS2MAPTGRM5GRM1KDM4E | |
| SCHEMBL5611633 | 0.88 | MAPT (0.43) | PTGS2MAPTGRM5GRM1KDM4E | |
| SCHEMBL5611689 | 0.86 | KDM4E (0.43) | PTGS2KDM4EMAPK1ADORA3ALDH1A1 | |
| SCHEMBL1688969 | 0.85 | MAPT (0.49) | PTGS2MAPTGRM5GRM1ALDH1A1 | |
| SCHEMBL1688906 | 0.83 | TDO2 (0.45) | PTGS2KDM4EMAPK1ALDH1A1HPGD | |
| SCHEMBL1688884 | 0.83 | CNR1 (0.45) | MAPTKDM4EMAPK1ALDH1A1HPGD | |
| SCHEMBL1688942 | 0.82 | CNR1 (0.43) | KDM4EMAPK1KMT2A | |
| SCHEMBL5611629 | 0.81 | SMN1; SMN2 (0.41) | PTGS2MAPTGRM5GRM1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1807429-A2 | COMPOUNDS AND COMPOSITIONS AS INHIBITORS OF CANNABINOID RECEPTOR 1 ACTIVITY | IRM, LLC (BM) | 2007-07-18 | — | — | EP | claimed |
| WO-2006047516-A2 | COMPOUNDS AND COMPOSITIONS AS INHIBITORS OF CANNABINOID RECEPTOR 1 ACTIVITY | IRM LLC (BM) | 2006-05-04 | — | — | WO | claimed |