Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHFR | P00374 | 6/20 | 0.46 |
| ▸ | TDP2 | O95551 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | PIM1 | P11309 | 1/20 | 0.38 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.38 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.38 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.38 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.38 |
| ▸ | DHODH | Q02127 | 1/20 | 0.38 |
| ▸ | TNKS | O95271 | 1/20 | 0.37 |
| ▸ | WNT3A | P56704 | 1/20 | 0.37 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.37 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.36 |
| ▸ | ARF6 | P62330 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5611667 | 0.88 | DHFR (0.56) | DHFRTDP2ALDH1A1HPGDTSHR | |
| SCHEMBL4750784 | 0.83 | DHFR (0.53) | DHFRTDP2ALDH1A1HPGDTSHR | |
| SCHEMBL5611922 | 0.80 | DHFR (0.58) | DHFRTDP2ALDH1A1HPGDTSHR | |
| SCHEMBL5611669 | 0.79 | DHFR (0.51) | DHFRTDP2ALDH1A1HPGDTSHR | |
| SCHEMBL4510952 | 0.78 | DHFR (0.65) | DHFRALDH1A1TNKSWNT3ATNKS2 | |
| SCHEMBL5611811 | 0.77 | DHFR (0.61) | DHFRTDP2ALDH1A1HPGDTSHR | |
| SCHEMBL1689135 | 0.77 | DHFR (0.49) | DHFRALDH1A1HPGDTSHRDHODH | |
| SCHEMBL5611631 | 0.77 | DHFR (0.66) | DHFRALDH1A1HPGDDHODHTNKS | |
| SCHEMBL5611470 | 0.76 | DHFR (0.55) | DHFRALDH1A1HPGDTSHRTNKS | |
| SCHEMBL5611734 | 0.76 | DHFR (0.55) | DHFRALDH1A1HPGDTSHRTNKS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1807429-A2 | COMPOUNDS AND COMPOSITIONS AS INHIBITORS OF CANNABINOID RECEPTOR 1 ACTIVITY | IRM, LLC (BM) | 2007-07-18 | — | — | EP | claimed |
| WO-2006047516-A2 | COMPOUNDS AND COMPOSITIONS AS INHIBITORS OF CANNABINOID RECEPTOR 1 ACTIVITY | IRM LLC (BM) | 2006-05-04 | — | — | WO | claimed |