SCHEMBL16890212

SCHEMBL16890212

c1cc(Oc2ccc(-n3c4ccccc4c4ccccc43)cc2)cc(Oc2ccc(-n3c4ccccc4c4ccccc43)cc2)c1

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 1/20 0.53
ATM Q13315 1/20 0.53
L3MBTL1 Q9Y468 1/20 0.53
SMN1; SMN2 Q16637 2/20 0.46
MEN1 O00255 1/20 0.46
MITF O75030 1/20 0.46
ALDH1A1 P00352 1/20 0.46
GAA P10253 1/20 0.46
MAPT P10636 1/20 0.46
GFER P55789 1/20 0.46
KMT2A Q03164 1/20 0.46
NLRP1 Q9C000 1/20 0.46
NOD2 Q9HC29 1/20 0.46
PTPN1 P18031 1/20 0.43
NTRK1 P04629 2/20 0.42
IGF1R P08069 2/20 0.42
FGFR1 P11362 2/20 0.42
NTRK2 Q16620 2/20 0.42
NTRK3 Q16288 1/20 0.42
PPARG P37231 5/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16890387 0.94 KDM4E (0.52) KDM4EATML3MBTL1SMN1; SMN2MEN1
SCHEMBL3904085 0.91 KDM4E (0.65) KDM4EATML3MBTL1PTPN1NTRK1
SCHEMBL4570440 0.91 KDM4E (0.64) KDM4EATML3MBTL1SMN1; SMN2MEN1
SCHEMBL13049621 0.91 KDM4E (0.64) KDM4EATML3MBTL1SMN1; SMN2MEN1
SCHEMBL16890333 0.89 KDM4E (0.57) KDM4EATML3MBTL1SMN1; SMN2MEN1
SCHEMBL16889994 0.88 KDM4E (0.58) KDM4EATML3MBTL1SMN1; SMN2MEN1
SCHEMBL20375798 0.88 L3MBTL1 (0.42) KDM4EATML3MBTL1MEN1ALDH1A1
SCHEMBL16890211 0.88 KDM4E (0.49) KDM4EATML3MBTL1PTPN1NTRK1
SCHEMBL28477376 0.87 KDM4E (0.61) KDM4EATML3MBTL1NTRK1IGF1R
SCHEMBL28475204 0.86 L3MBTL1 (0.60) KDM4EATML3MBTL1PTPN1NTRK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3109253-B1 POLYCYCLIC AROMATIC COMPOUNDS AND THEIR USE AS ORGANIC DEVICE MATERIAL KWANSEI GAKUIN EDUCATIONAL FOUND (JP) 2018-10-24 EP disclosed
EP-3345911-A1 POLYCYCLIC AROMATIC COMPOUNDS AND THEIR USE AS ORGANIC DEVICE MATERIAL Kwansei Gakuin Educational Foundation (JP) 2018-07-11 EP disclosed
EP-3345911-A1 POLYCYCLIC AROMATIC COMPOUNDS AND THEIR USE AS ORGANIC DEVICE MATERIAL Kwansei Gakuin Educational Foundation (JP) 2018-07-11 EP disclosed
EP-3109253-A1 POLYCYCLIC AROMATIC COMPOUND Kwansei Gakuin Educational Foundation (JP) 2016-12-28 EP disclosed
WO-2015102118-A1 POLYCYCLIC AROMATIC COMPOUND 学校法人関西学院 2015-07-09 WO disclosed