Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.32 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | RECQL | P46063 | 1/20 | 0.31 |
| ▸ | CASP6 | P55212 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | ELAVL1 | Q15717 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.30 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.30 |
| ▸ | HTR1A | P08908 | 1/20 | 0.30 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.30 |
| ▸ | HTR2C | P28335 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5792421 | 0.85 | ALDH1A1 (0.35) | GAAHSD17B10KDM4EMEN1ALDH1A1 | |
| SCHEMBL2565711 | 0.83 | L3MBTL1 (0.32) | GAAALDH1A1POLBKMT2AL3MBTL1 | |
| SCHEMBL9101971 | 0.80 | PTGDR2 (0.39) | GAAHSD17B10HCRTR1HCRTR2KDM4E | |
| SCHEMBL16712212 | 0.80 | CHRNB2 (0.43) | GAAHSD17B10KDM4EMEN1ALDH1A1 | |
| SCHEMBL28909489 | 0.79 | HSD11B1 (0.33) | GAAHSD17B10KDM4EMEN1ALDH1A1 | |
| SCHEMBL28571617 | 0.79 | HTT (0.44) | ALDH1A1POLBMAPTKMT2A | |
| SCHEMBL28571618 | 0.79 | HTT (0.44) | ALDH1A1POLBMAPTKMT2A | |
| SCHEMBL7796621 | 0.78 | CHRNB2 (0.37) | GAAHSD17B10KDM4EMEN1ALDH1A1 | |
| SCHEMBL29612032 | 0.78 | MPL (0.34) | GAAHSD17B10HCRTR1HCRTR2KDM4E | |
| SCHEMBL30764027 | 0.77 | PTGDR2 (0.43) | HCRTR1HCRTR2L3MBTL1CHRNB2CHRNA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2894151-B1 | IMIDAZOLINE DERIVATIVES, PREPARATION METHODS THEREOF, AND THEIR APPLICATIONS IN MEDICINE | Shanghai hengrui pharmaceutical co ltd (CN) | 2020-11-11 | — | — | EP | disclosed |
| US-9895355-B2 | Methods of treating androgen receptor-mediated disorders with imidazoline derivatives | Shanghai Hengru Pharmaceutical Co., Ltd. (CN) | 2018-02-20 | — | — | US | disclosed |
| US-20170128422-A1 | METHODS OF TREATING ANDROGEN RECEPTOR-MEDIATED DISORDERS WITH IMIDAZOLINE DERIVATIVES | Shanghai hengrui pharmaceutical co ltd (CN) | 2017-05-11 | — | — | US | disclosed |
| US-9586947-B2 | Imidazoline derivatives, preparation methods thereof, and their applications in medicine | SHANGHAI HENGRUI PHARMACEUTICAL CO., LTD. (CN) | 2017-03-07 | — | — | US | disclosed |
| US-20150225381-A1 | IMIDAZOLINE DERIVATIVES, PREPARATION METHODS THEREOF, AND THEIR APPLICATIONS IN MEDICINE | JIANGSU HENGRUI MEDICINE CO., LTD. (CN) | 2015-08-13 | — | — | US | disclosed |
| EP-2894151-A1 | IMIDAZOLINE DERIVATIVES, PREPARATION METHODS THEREOF, AND THEIR APPLICATIONS IN MEDICINE | Shanghai Hengrui Pharmaceutical Co. Ltd. (CN) | 2015-07-15 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170128422-A1 | METHODS OF TREATING ANDROGEN RECEPTOR-MEDIATED DISORDERS WITH IMIDAZOLINE DERIVATIVES | NR5A1, ESRRA, ESRRB | GAA 2756/4885HSD17B10 81/4885HCRTR1 2127/4885 |
| US-20150225381-A1 | IMIDAZOLINE DERIVATIVES, PREPARATION METHODS THEREOF, AND THEIR APPLICATIONS IN MEDICINE | AR, KLK3, NR5A1 | GAA 3921/4885HSD17B10 1389/4885HCRTR1 4411/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.