Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | DPP4 | P27487 | 1/20 | 0.32 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30747215 | 0.76 | ALDH1A1 (0.36) | ALDH1A1DPP4CYP2E1CYP3A4CYP2A6 | |
| SCHEMBL16901839 | 0.76 | ALDH1A1 (0.46) | ALDH1A1DPP4CYP2E1CYP3A4CYP2A6 | |
| SCHEMBL30762009 | 0.76 | DRD1 (0.39) | ALDH1A1DPP4CYP2E1CYP3A4CYP2A6 | |
| SCHEMBL16894463 | 0.75 | ALDH1A1 (0.39) | ALDH1A1DPP4CYP2E1CYP3A4CYP2A6 | |
| SCHEMBL20391127 | 0.74 | ALDH1A1 (0.34) | ALDH1A1DPP4 | |
| SCHEMBL16901840 | 0.73 | ALDH1A1 (0.43) | ALDH1A1DPP4 | |
| SCHEMBL16894359 | 0.72 | ALDH1A1 (0.37) | ALDH1A1DPP4 | |
| SCHEMBL28207921 | 0.72 | ALDH1A1 (0.42) | ALDH1A1CYP3A4 | |
| SCHEMBL18626712 | 0.72 | PRMT6 (0.31) | — | |
| SCHEMBL11764446 | 0.71 | ALDH1A1 (0.46) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2861570-B1 | ANTIBACTERIAL AGENTS: ARYL MYXOPYRONIN DERIVATIVES | UNIV RUTGERS (US) | 2018-07-18 | — | — | EP | disclosed |
| EP-2861570-B1 | ANTIBACTERIAL AGENTS: ARYL MYXOPYRONIN DERIVATIVES | UNIV RUTGERS (US) | 2018-07-18 | — | — | EP | disclosed |
| US-9592221-B2 | Antibacterial agents: aryl myxopyronin derivatives | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (US) | 2017-03-14 | — | — | US | disclosed |
| US-9592221-B2 | Antibacterial agents: aryl myxopyronin derivatives | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (US) | 2017-03-14 | — | — | US | disclosed |
| US-9592221-B2 | Antibacterial agents: aryl myxopyronin derivatives | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (US) | 2017-03-14 | — | — | US | disclosed |
| US-20160263083-A1 | ANTIBACTERIAL AGENTS: ARYL MYXOPYRONIN DERIVATIVES | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (US) | 2016-09-15 | — | — | US | disclosed |
| US-20160263083-A1 | ANTIBACTERIAL AGENTS: ARYL MYXOPYRONIN DERIVATIVES | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (US) | 2016-09-15 | — | — | US | disclosed |
| US-20160263083-A1 | ANTIBACTERIAL AGENTS: ARYL MYXOPYRONIN DERIVATIVES | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (US) | 2016-09-15 | — | — | US | disclosed |
| US-9315495-B2 | Antibacterial agents: aryl myxopyronin derivatives | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (US) | 2016-04-19 | — | — | US | disclosed |
| US-9315495-B2 | Antibacterial agents: aryl myxopyronin derivatives | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (US) | 2016-04-19 | — | — | US | disclosed |
| US-9315495-B2 | Antibacterial agents: aryl myxopyronin derivatives | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (US) | 2016-04-19 | — | — | US | disclosed |
| US-20150197512-A1 | ANTIBACTERIAL AGENTS: ARYL MYXOPYRONIN DERIVATIVES | PROVID PHARMACEUTICALS INC. | 2015-07-16 | — | — | US | disclosed |
| US-20150197512-A1 | ANTIBACTERIAL AGENTS: ARYL MYXOPYRONIN DERIVATIVES | PROVID PHARMACEUTICALS INC. | 2015-07-16 | — | — | US | disclosed |
| US-20150197512-A1 | ANTIBACTERIAL AGENTS: ARYL MYXOPYRONIN DERIVATIVES | PROVID PHARMACEUTICALS INC. | 2015-07-16 | — | — | US | disclosed |
| EP-2861570-A1 | ANTIBACTERIAL AGENTS: ARYL MYXOPYRONIN DERIVATIVES | Rutgers, The State University of New Jersey (US) | 2015-04-22 | — | — | EP | disclosed |
| WO-2013192352-A1 | ANTIBACTERIAL AGENTS: ARYL MYXOPYRONIN DERIVATIVES | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (US) | 2013-12-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160263083-A1 | ANTIBACTERIAL AGENTS: ARYL MYXOPYRONIN DERIVATIVES | POLRMT, POLR1C, FBL | ALDH1A1 1785/4885DPP4 2343/4885CYP2E1 1300/4885 |
| US-20150197512-A1 | ANTIBACTERIAL AGENTS: ARYL MYXOPYRONIN DERIVATIVES | FBL, POLRMT, POLR1C | ALDH1A1 1561/4885DPP4 3048/4885CYP2E1 1484/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.