Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 2/20 | 0.48 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.48 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.48 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.48 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.39 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.39 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.39 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.39 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 5/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.34 |
| ▸ | RELA | Q04206 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12897992 | 0.88 | OPRM1 (0.42) | AKR1B10AKR1C4AKR1C3AKR1C2AKR1C1 | |
| SCHEMBL11823620 | 0.86 | PDE4A (0.51) | PDE4APDE4BPDE4CPDE4DOPRM1 | |
| SCHEMBL2290702 | 0.86 | PDE4A (0.48) | PDE4APDE4BPDE4CPDE4DOPRM1 | |
| SCHEMBL16897522 | 0.81 | OPRM1 (0.38) | AKR1B10AKR1C4AKR1C3AKR1C2AKR1C1 | |
| SCHEMBL2290710 | 0.80 | PDE4B (0.65) | PDE4APDE4BPDE4CPDE4DNPC1 | |
| SCHEMBL18854340 | 0.79 | OPRM1 (0.37) | PDE4APDE4BPDE4CPDE4DAKR1B10 | |
| SCHEMBL2290555 | 0.79 | PDE4B (0.63) | PDE4APDE4BPDE4CPDE4DNPC1 | |
| SCHEMBL1559063 | 0.78 | PDE4A (0.45) | PDE4APDE4BPDE4CPDE4DOPRM1 | |
| SCHEMBL11093941 | 0.78 | OPRM1 (0.58) | PDE4APDE4BPDE4CPDE4DOPRM1 | |
| SCHEMBL16906026 | 0.77 | CYP1A2 (0.35) | AKR1B10AKR1C4AKR1C3AKR1C2AKR1C1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3092239-B1 | ARYL SULTAM DERIVATIVES AS RORC MODULATORS | HOFFMANN LA ROCHE (CH) | 2019-10-02 | — | — | EP | disclosed |
| EP-3092239-B1 | ARYL SULTAM DERIVATIVES AS RORC MODULATORS | HOFFMANN LA ROCHE (CH) | 2019-10-02 | — | — | EP | disclosed |
| US-10131644-B2 | Aryl sultam derivatives as RORc modulators | GENENTECH, INC. (US) | 2018-11-20 | — | — | US | disclosed |
| US-20170137393-A1 | ARYL SULTAM DERIVATIVES AS RORc MODULATORS | GENENTECH, INC. (US) | 2017-05-18 | — | — | US | disclosed |
| US-20170137393-A1 | ARYL SULTAM DERIVATIVES AS RORc MODULATORS | GENENTECH, INC. (US) | 2017-05-18 | — | — | US | disclosed |
| US-20170137393-A1 | ARYL SULTAM DERIVATIVES AS RORc MODULATORS | GENENTECH, INC. (US) | 2017-05-18 | — | — | US | disclosed |
| EP-3092239-A1 | ARYL SULTAM DERIVATIVES AS RORc MODULATORS | F. Hoffmann-La Roche AG (CH) | 2016-11-16 | — | — | EP | disclosed |
| WO-2015104354-A1 | ARYL SULTAM DERIVATIVES AS RORc MODULATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2015-07-16 | — | — | WO | disclosed |
| WO-2015104354-A1 | ARYL SULTAM DERIVATIVES AS RORc MODULATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2015-07-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10131644-B2 | Aryl sultam derivatives as RORc modulators | RORC, RORB, RORA | PDE4A 1521/4885PDE4B 2389/4885PDE4C 1860/4885 |
| US-20170137393-A1 | ARYL SULTAM DERIVATIVES AS RORc MODULATORS | RORC, RORB, RORA | PDE4A 1521/4885PDE4B 2389/4885PDE4C 1860/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.