Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.66 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.66 |
| ▸ | HPGD | P15428 | 1/20 | 0.66 |
| ▸ | HTT | P42858 | 1/20 | 0.66 |
| ▸ | NCF1 | P14598 | 1/20 | 0.64 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.61 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.59 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.59 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.59 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.59 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.58 |
| ▸ | HTR1A | P08908 | 4/20 | 0.56 |
| ▸ | DRD2 | P14416 | 4/20 | 0.56 |
| ▸ | NOS1 | P29475 | 1/20 | 0.54 |
| ▸ | FAAH | O00519 | 1/20 | 0.53 |
| ▸ | DRD4 | P21917 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24061140 | 0.88 | HRH3 (0.58) | ALDH1A1KDM4EHPGDHTTNCF1 | |
| SCHEMBL3140256 | 0.88 | NCF1 (0.57) | ALDH1A1KDM4EHPGDHTTNCF1 | |
| SCHEMBL4477670 | 0.86 | HDAC1 (0.57) | ALDH1A1KDM4EHPGDHTTNCF1 | |
| SCHEMBL11196105 | 0.86 | NCF1 (0.83) | ALDH1A1KDM4EHPGDHTTNCF1 | |
| SCHEMBL3425973 | 0.84 | CYP2D6 (0.65) | ALDH1A1KDM4EHRH3CYP2D6CYP2C9 | |
| 4-(Biphenyl-4-Ylmethyl)Morpholine SCHEMBL1691308 | 0.84 | HRH3 (0.85) | ALDH1A1HTTHRH3CYP3A4CYP2D6 | |
| SCHEMBL26378178 | 0.84 | KCNH2 (0.54) | ALDH1A1KDM4EHPGDHTTNCF1 | |
| SCHEMBL16378748 | 0.84 | HRH3 (0.54) | ALDH1A1KDM4EHPGDHTTNCF1 | |
| SCHEMBL6200777 | 0.84 | SIGMAR1 (0.71) | ALDH1A1KDM4EHPGDHTTNCF1 | |
| SCHEMBL102338 | 0.84 | SIGMAR1 (0.71) | ALDH1A1KDM4EHPGDHTTNCF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105008348-B | Pyrazolylbenzo [ D ] imidazole derivatives | 赛隆制药股份公司 | 2018-07-10 | — | — | CN | disclosed |
| CN-101490063-B | Fluoroboron compound, aromatic ring aminomethylating agent comprising the same, and method for producing compound having aminomethyl aromatic ring using the aromatic ring aminomethylating agent | Sanitary Material R&D Management Co.,Ltd. (JP) | 2014-10-22 | — | — | CN | disclosed |
| EP-2039697-B1 | FLUOROBORON COMPOUND, AMINOMETHYLATING AGENT FOR AROMATIC RING COMPRISING THE COMPOUND, AND PROCESS FOR PRODUCTION OF COMPOUND HAVING AMINOMETHYL-AROMATIC RING USING THE AMINOMETHYLATING AGENT | EISAI R&D MAN CO LTD (JP) | 2013-09-04 | — | — | EP | disclosed |
| EP-2039697-B1 | FLUOROBORON COMPOUND, AMINOMETHYLATING AGENT FOR AROMATIC RING COMPRISING THE COMPOUND, AND PROCESS FOR PRODUCTION OF COMPOUND HAVING AMINOMETHYL-AROMATIC RING USING THE AMINOMETHYLATING AGENT | EISAI R&D MAN CO LTD (JP) | 2013-09-04 | — | — | EP | disclosed |
| US-8524946-B2 | Fluoroboron compound, aminomethylating agent for aromatic ring made of the same, and production method of compound containing aminomethyl aromatic ring using aminomethylating agent | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2013-09-03 | — | — | US | disclosed |
| US-8524946-B2 | Fluoroboron compound, aminomethylating agent for aromatic ring made of the same, and production method of compound containing aminomethyl aromatic ring using aminomethylating agent | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2013-09-03 | — | — | US | disclosed |
| US-8524946-B2 | Fluoroboron compound, aminomethylating agent for aromatic ring made of the same, and production method of compound containing aminomethyl aromatic ring using aminomethylating agent | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2013-09-03 | — | — | US | disclosed |
| US-20120010403-A1 | FLUOROBORON COMPOUND, AMINOMETHYLATING AGENT FOR AROMATIC RING MADE OF THE SAME, AND PRODUCTION METHOD OF COMPOUND CONTAINING AMINOMETHYL AROMATIC RING USING AMINOMETHYLATING AGENT | TANAKA KEIGO (JP) | 2012-01-12 | — | — | US | disclosed |
| US-20120010403-A1 | FLUOROBORON COMPOUND, AMINOMETHYLATING AGENT FOR AROMATIC RING MADE OF THE SAME, AND PRODUCTION METHOD OF COMPOUND CONTAINING AMINOMETHYL AROMATIC RING USING AMINOMETHYLATING AGENT | TANAKA KEIGO (JP) | 2012-01-12 | — | — | US | disclosed |
| US-20120010403-A1 | FLUOROBORON COMPOUND, AMINOMETHYLATING AGENT FOR AROMATIC RING MADE OF THE SAME, AND PRODUCTION METHOD OF COMPOUND CONTAINING AMINOMETHYL AROMATIC RING USING AMINOMETHYLATING AGENT | TANAKA KEIGO (JP) | 2012-01-12 | — | — | US | disclosed |
| US-8044216-B2 | Fluoroboron compound, aminomethylating agent for aromatic ring made of the same, and production method of compound containing aminomethyl aromatic ring using aminomethylating agent | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2011-10-25 | — | — | US | disclosed |
| US-8044216-B2 | Fluoroboron compound, aminomethylating agent for aromatic ring made of the same, and production method of compound containing aminomethyl aromatic ring using aminomethylating agent | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2011-10-25 | — | — | US | disclosed |
| US-8044216-B2 | Fluoroboron compound, aminomethylating agent for aromatic ring made of the same, and production method of compound containing aminomethyl aromatic ring using aminomethylating agent | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2011-10-25 | — | — | US | disclosed |
| CN-101490063-A | Fluoroboron compound, aromatic ring aminomethylating agent comprising the same, and method for producing compound having aminomethyl aromatic ring using the aromatic ring aminomethylating agent | EISAI R&D MAN CO LTD (JP) | 2009-07-22 | — | — | CN | disclosed |
| EP-2039697-A1 | FLUOROBORON COMPOUND, AMINOMETHYLATING AGENT FOR AROMATIC RING COMPRISING THE COMPOUND, AND PROCESS FOR PRODUCTION OF COMPOUND HAVING AMINOMETHYL-AROMATIC RING USING THE AMINOMETHYLATING AGENT | Eisai R&D Management Co., Ltd. (JP) | 2009-03-25 | — | — | EP | disclosed |
| EP-2039697-A1 | FLUOROBORON COMPOUND, AMINOMETHYLATING AGENT FOR AROMATIC RING COMPRISING THE COMPOUND, AND PROCESS FOR PRODUCTION OF COMPOUND HAVING AMINOMETHYL-AROMATIC RING USING THE AMINOMETHYLATING AGENT | Eisai R&D Management Co., Ltd. (JP) | 2009-03-25 | — | — | EP | disclosed |
| US-20080015351-A1 | Fluoroboron compound, aminomethylating agent for aromatic ring made of the same, and production method of compound containing aminomethyl aromatic ring using aminomethylating agent | EISAI R&D MANAGEMENT CO., LTD. | 2008-01-17 | — | — | US | disclosed |
| US-20080015351-A1 | Fluoroboron compound, aminomethylating agent for aromatic ring made of the same, and production method of compound containing aminomethyl aromatic ring using aminomethylating agent | EISAI R&D MANAGEMENT CO., LTD. | 2008-01-17 | — | — | US | disclosed |
| US-20080015351-A1 | Fluoroboron compound, aminomethylating agent for aromatic ring made of the same, and production method of compound containing aminomethyl aromatic ring using aminomethylating agent | EISAI R&D MANAGEMENT CO., LTD. | 2008-01-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080015351-A1 | Fluoroboron compound, aminomethylating agent for aromatic ring made of the same, and production method of compound containing aminomethyl aromatic ring using aminomethylating agent | PRMT6, MLLT3, PRMT3 | ALDH1A1 1988/4885KDM4E 276/4885HPGD 4448/4885 |
| US-20120010403-A1 | FLUOROBORON COMPOUND, AMINOMETHYLATING AGENT FOR AROMATIC RING MADE OF THE SAME, AND PRODUCTION METHOD OF COMPOUND CONTAINING AMINOMETHYL AROMATIC RING USING AMINOMETHYLATING AGENT | PRMT6, MLLT3, PRMT3 | ALDH1A1 1988/4885KDM4E 276/4885HPGD 4448/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.