Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 10/20 | 1.00 |
| ▸ | NPC1 | O15118 | 9/20 | 1.00 |
| ▸ | MAPT | P10636 | 8/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 5/20 | 1.00 |
| ▸ | HTT | P42858 | 4/20 | 1.00 |
| ▸ | OPRK1 | P41145 | 4/20 | 1.00 |
| ▸ | LMNA | P02545 | 4/20 | 1.00 |
| ▸ | MEN1 | O00255 | 4/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 1.00 |
| ▸ | AGTR1 | P30556 | 2/20 | 1.00 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 1.00 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.69 |
| ▸ | PKM | P14618 | 3/20 | 0.69 |
| ▸ | POLB | P06746 | 2/20 | 0.69 |
| ▸ | GAA | P10253 | 2/20 | 0.59 |
| ▸ | TP53 | P04637 | 2/20 | 0.55 |
| ▸ | TNF | P01375 | 1/20 | 0.54 |
| ▸ | CRHBP | P24387 | 1/20 | 0.54 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.54 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3049281 | 0.84 | LMNA (0.77) | RAB9ANPC1MAPTKMT2AHTT | |
| SCHEMBL3792415 | 0.77 | RAB9A (0.70) | RAB9ANPC1MAPTKMT2AHTT | |
| SCHEMBL14808362 | 0.77 | RAB9A (0.65) | RAB9ANPC1MAPTKMT2AHTT | |
| SCHEMBL3044982 | 0.76 | RAB9A (0.68) | RAB9ANPC1MAPTKMT2AHTT | |
| SCHEMBL31504583 | 0.76 | RAB9A (0.64) | RAB9ANPC1MAPTKMT2AHTT | |
| SCHEMBL21589413 | 0.76 | NPC1 (0.65) | RAB9ANPC1MAPTKMT2AHTT | |
| SCHEMBL27004512 | 0.76 | RAB9A (0.64) | RAB9ANPC1MAPTKMT2AHTT | |
| SCHEMBL19612102 | 0.75 | RAB9A (0.60) | RAB9ANPC1MAPTKMT2AHTT | |
| SCHEMBL26884128 | 0.75 | KMT2A (0.65) | RAB9ANPC1MAPTKMT2AHTT | |
| SCHEMBL6229312 | 0.75 | NPC1 (0.76) | RAB9ANPC1MAPTKMT2AHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10787439-B2 | Compounds and methods for activating the apoptotic arm of the unfolded protein response | UNIVERSITY OF KANSAS (US) | 2020-09-29 | — | — | US | disclosed |
| US-20170334889-A1 | COMPOUNDS AND METHODS FOR ACTIVATING THE APOPTOTIC ARM OF THE UNFOLDED PROTEIN RESPONSE | UNIVERSITY OF KANSAS | 2017-11-23 | — | — | US | disclosed |
| US-20170334889-A1 | COMPOUNDS AND METHODS FOR ACTIVATING THE APOPTOTIC ARM OF THE UNFOLDED PROTEIN RESPONSE | UNIVERSITY OF KANSAS | 2017-11-23 | — | — | US | disclosed |
| US-9732067-B2 | Compounds and methods for activating the apoptotic arm of the unfolded protein response | UNIVERSITY OF KANSAS (US) | 2017-08-15 | — | — | US | disclosed |
| US-9732067-B2 | Compounds and methods for activating the apoptotic arm of the unfolded protein response | UNIVERSITY OF KANSAS (US) | 2017-08-15 | — | — | US | disclosed |
| US-20150203477-A1 | COMPOUNDS AND METHODS FOR ACTIVATING THE APOPTOTIC ARM OF THE UNFOLDED PROTEIN RESPONSE | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2015-07-23 | — | — | US | disclosed |
| US-20150203477-A1 | COMPOUNDS AND METHODS FOR ACTIVATING THE APOPTOTIC ARM OF THE UNFOLDED PROTEIN RESPONSE | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2015-07-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150203477-A1 | COMPOUNDS AND METHODS FOR ACTIVATING THE APOPTOTIC ARM OF THE UNFOLDED PROTEIN RESPONSE | IAPP, TFEB, GBA1 | RAB9A 1553/4885NPC1 895/4885MAPT 417/4885 |
| US-10787439-B2 | Compounds and methods for activating the apoptotic arm of the unfolded protein response | IAPP, TFEB, GBA1 | RAB9A 1553/4885NPC1 895/4885MAPT 417/4885 |
| US-20170334889-A1 | COMPOUNDS AND METHODS FOR ACTIVATING THE APOPTOTIC ARM OF THE UNFOLDED PROTEIN RESPONSE | IAPP, TFEB, GBA1 | RAB9A 1553/4885NPC1 895/4885MAPT 417/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.