Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR2 | Q92731 | 2/20 | 0.52 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.51 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.51 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | RECQL | P46063 | 1/20 | 0.49 |
| ▸ | CA9 | Q16790 | 5/20 | 0.49 |
| ▸ | CA12 | O43570 | 4/20 | 0.49 |
| ▸ | NQO1 | P15559 | 1/20 | 0.48 |
| ▸ | MAOB | P27338 | 1/20 | 0.46 |
| ▸ | ESR1 | P03372 | 1/20 | 0.46 |
| ▸ | PIM1 | P11309 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14163793 | 0.89 | ESR2 (0.54) | ESR2CSNK2A2CSNK2BCSNK2A1MAPT | |
| SCHEMBL26766495 | 0.89 | ESR2 (0.50) | ESR2CSNK2A2CSNK2BCSNK2A1MAPT | |
| SCHEMBL12800978 | 0.84 | CSNK2A2 (0.53) | CSNK2A2CSNK2BCSNK2A1MAPTCYP3A4 | |
| SCHEMBL26768424 | 0.82 | CDC25A (0.48) | ESR2CSNK2A2CSNK2BCSNK2A1MAPT | |
| SCHEMBL19217398 | 0.81 | CSNK2A2 (0.62) | CSNK2A2CSNK2BCSNK2A1MAPTCYP3A4 | |
| SCHEMBL23693655 | 0.80 | CSNK2A2 (0.49) | CSNK2A2CSNK2BCSNK2A1MAPTCYP3A4 | |
| SCHEMBL21756078 | 0.80 | MAPT (0.47) | CSNK2A2CSNK2BCSNK2A1MAPTCYP3A4 | |
| SCHEMBL16801876 | 0.80 | NPC1 (0.64) | MAPTMAPK1CA9CA12PIM1 | |
| SCHEMBL16802064 | 0.80 | SMN1; SMN2 (0.64) | MAPTCYP3A4MAPK1TP53NQO1 | |
| SCHEMBL862799 | 0.79 | PDE2A (0.56) | ESR2MAPTCYP3A4MAPK1NQO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3197887-B1 | HETEROCYCLIC COMPOUNDS WITH BENZO[C]COUMARIN-STRUCTURES | MERCK PATENT GMBH (DE) | 2020-09-23 | — | — | EP | disclosed |
| US-10377766-B2 | Heterocyclic compounds with benzo(c)coumarin-structures | MERCK PATENT GMBH (DE) | 2019-08-13 | — | — | US | disclosed |
| US-10000694-B2 | Materials for organic electroluminescent devices | MERCK PATENT GMBH (DE) | 2018-06-19 | — | — | US | disclosed |
| US-10000694-B2 | Materials for organic electroluminescent devices | MERCK PATENT GMBH (DE) | 2018-06-19 | — | — | US | disclosed |
| EP-3094703-B1 | MATERIALS FOR ORGANIC ELECTROLUMINESCENT DEVICES | MERCK PATENT GMBH (DE) | 2018-02-07 | — | — | EP | disclosed |
| US-20170298077-A1 | HETEROCYCLIC COMPOUNDS WITH BENZO(C)COUMARIN-STRUCTURES | MERCK PATENT GMBH (DE) | 2017-10-19 | — | — | US | disclosed |
| US-20170298077-A1 | HETEROCYCLIC COMPOUNDS WITH BENZO(C)COUMARIN-STRUCTURES | MERCK PATENT GMBH (DE) | 2017-10-19 | — | — | US | disclosed |
| US-20160326429-A1 | MATERIALS FOR ORGANIC ELECTROLUMINESCENT DEVICES | MERCK PATENT GMBH (DE) | 2016-11-10 | — | — | US | disclosed |
| WO-2016045769-A1 | HETEROCYCLIC COMPOUNDS WITH BENZO[C]COUMARIN-STRUCTURES | MERCK PATENT GMBH (DE) | 2016-03-31 | — | — | WO | disclosed |
| WO-2015106789-A1 | MATERIALS FOR ORGANIC ELECTROLUMINESCENT DEVICES | MERCK PATENT GMBH (DE) | 2015-07-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10000694-B2 | Materials for organic electroluminescent devices | OR10J3, EPCAM, L1CAM | ESR2 366/4885CSNK2A2 4383/4885CSNK2B 4588/4885 |
| US-20170298077-A1 | HETEROCYCLIC COMPOUNDS WITH BENZO(C)COUMARIN-STRUCTURES | NISCH, SIRT3, NQO1 | ESR2 736/4885CSNK2A2 2569/4885CSNK2B 2785/4885 |
| US-20160326429-A1 | MATERIALS FOR ORGANIC ELECTROLUMINESCENT DEVICES | OR10J3, EPCAM, L1CAM | ESR2 366/4885CSNK2A2 4383/4885CSNK2B 4588/4885 |
| US-10377766-B2 | Heterocyclic compounds with benzo(c)coumarin-structures | NISCH, SIRT3, NQO1 | ESR2 736/4885CSNK2A2 2569/4885CSNK2B 2785/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.